将脂肪甘油三酯脂肪酶作为治疗代谢功能障碍相关性脂肪性肝炎的靶点：肝脏和肠道 PPARα 的作用

IF 3.7 2区生物学 Q1 BIOCHEMICAL RESEARCH METHODS ACS Synthetic Biology Pub Date : 2024-11-13 DOI:10.1016/j.jhep.2024.10.046

Frank J. Gonzalez, Yangliu Xia

{"title":"将脂肪甘油三酯脂肪酶作为治疗代谢功能障碍相关性脂肪性肝炎的靶点：肝脏和肠道 PPARα 的作用","authors":"Frank J. Gonzalez, Yangliu Xia","doi":"10.1016/j.jhep.2024.10.046","DOIUrl":null,"url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Financial support</h2>Funded by the National Cancer Institute Intramural Research Program.</section></section><section><section><h2>Declaration of Competing Interest</h2>The authors declare no conflicts of interest that pertain to this work.Please refer to the accompanying ICMJE disclosure forms for further details.Adipose triglyceride lipase (ATGL), encoded by the <em>PNPLA2</em> gene in humans, hydrolyzes triacylglycerols to diacylglycerols. <em>PNPLA2</em> is regulated by insulin, and under conditions of insulin resistance, increased adipocyte ATGL leads to excess production of free fatty acids that are transported to the liver resulting in metabolic dysfunction-associated</section></section>","PeriodicalId":26,"journal":{"name":"ACS Synthetic Biology","volume":"37 1","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Adipose triglyceride lipase as a target for treatment of metabolic dysfunction-associated steatohepatitis: the role of hepatic and intestinal PPARα\",\"authors\":\"Frank J. Gonzalez, Yangliu Xia\",\"doi\":\"10.1016/j.jhep.2024.10.046\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h2>Section snippets</h2><section><section><h2>Financial support</h2>Funded by the National Cancer Institute Intramural Research Program.</section></section><section><section><h2>Declaration of Competing Interest</h2>The authors declare no conflicts of interest that pertain to this work.Please refer to the accompanying ICMJE disclosure forms for further details.Adipose triglyceride lipase (ATGL), encoded by the <em>PNPLA2</em> gene in humans, hydrolyzes triacylglycerols to diacylglycerols. <em>PNPLA2</em> is regulated by insulin, and under conditions of insulin resistance, increased adipocyte ATGL leads to excess production of free fatty acids that are transported to the liver resulting in metabolic dysfunction-associated</section></section>\",\"PeriodicalId\":26,\"journal\":{\"name\":\"ACS Synthetic Biology\",\"volume\":\"37 1\",\"pages\":\"\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-11-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Synthetic Biology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jhep.2024.10.046\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Synthetic Biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jhep.2024.10.046","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}

引用次数: 0

摘要

部分片段财务支持由美国国家癌症研究所校内研究计划资助。利益冲突声明作者声明没有与本研究相关的利益冲突，详情请参见随附的 ICMJE 披露表。PNPLA2 受胰岛素调节，在胰岛素抵抗的条件下，脂肪细胞 ATGL 的增加会导致游离脂肪酸的过量产生，这些游离脂肪酸被运送到肝脏，从而导致代谢功能障碍相关的疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Adipose triglyceride lipase as a target for treatment of metabolic dysfunction-associated steatohepatitis: the role of hepatic and intestinal PPARα

Section snippets

Financial support

Funded by the National Cancer Institute Intramural Research Program.

Declaration of Competing Interest

The authors declare no conflicts of interest that pertain to this work.Please refer to the accompanying ICMJE disclosure forms for further details.Adipose triglyceride lipase (ATGL), encoded by the PNPLA2 gene in humans, hydrolyzes triacylglycerols to diacylglycerols. PNPLA2 is regulated by insulin, and under conditions of insulin resistance, increased adipocyte ATGL leads to excess production of free fatty acids that are transported to the liver resulting in metabolic dysfunction-associated

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

ACS Synthetic Biology 生物-

CiteScore

8.00

自引率

10.60%

发文量

380

审稿时长

6-12 weeks

期刊介绍： The journal is particularly interested in studies on the design and synthesis of new genetic circuits and gene products; computational methods in the design of systems; and integrative applied approaches to understanding disease and metabolism. Topics may include, but are not limited to: Design and optimization of genetic systems Genetic circuit design and their principles for their organization into programs Computational methods to aid the design of genetic systems Experimental methods to quantify genetic parts, circuits, and metabolic fluxes Genetic parts libraries: their creation, analysis, and ontological representation Protein engineering including computational design Metabolic engineering and cellular manufacturing, including biomass conversion Natural product access, engineering, and production Creative and innovative applications of cellular programming Medical applications, tissue engineering, and the programming of therapeutic cells Minimal cell design and construction Genomics and genome replacement strategies Viral engineering Automated and robotic assembly platforms for synthetic biology DNA synthesis methodologies Metagenomics and synthetic metagenomic analysis Bioinformatics applied to gene discovery, chemoinformatics, and pathway construction Gene optimization Methods for genome-scale measurements of transcription and metabolomics Systems biology and methods to integrate multiple data sources in vitro and cell-free synthetic biology and molecular programming Nucleic acid engineering.