中央型肺癌立体定向体放射治疗后的膈神经麻痹：病例报告。

IF 3.3 3区医学 Q2 ONCOLOGY Clinical lung cancer Pub Date : 2025-01-01 Epub Date: 2024-10-18 DOI:10.1016/j.cllc.2024.10.006

James C.H. Chow, Jeannie Y.K. Chik, Ka Man Cheung, Luke T.Y. Lee, Kam Hung Wong, Kwok Hung Au

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引用次数: 0

摘要

•放射诱导的膈神经麻痹是立体定向体放疗（SBRT）治疗中枢性肺肿瘤的罕见并发症。由此引起的半膈麻痹可能是有症状的，并损害呼吸功能。膈神经可以通过周围纵隔结构的标志在规划计算机断层图像上勾画。在计划靶体积非常接近的胸椎SBRT中，它应被视为标准的危险器官。•辐射诱发膈神经麻痹的剂量-毒性关系尚不清楚。然而，通过精心的计划优化，在计划目标体积内控制热点，呼吸运动管理和稳健的治疗验证，可以降低瘫痪的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Phrenic Nerve Palsy after Stereotactic Body Radiotherapy for Central Lung Cancer: A Case Report

•
Radiation-induced phrenic nerve palsy is an uncommon complication of stereotactic body radiotherapy (SBRT) for central lung tumor. The resultant paralysis of hemidiaphragm can be symptomatic and compromise respiratory function.
•
The phrenic nerve can be delineated on planning computed tomography images using landmarks of the surrounding mediastinal structures. It should be considered a standard organ at-risk in thoracic SBRT where the planning target volume is in close proximity.
•
The dose-toxicity relationship of radiation-induced phrenic nerve palsy remains unclear. Nevertheless, the risk of palsy may be reduced by careful plan optimization, hotspot control within the planning target volume, respiratory motion management, and robust treatment verification.

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来源期刊

Clinical lung cancer 医学-肿瘤学

CiteScore

7.00

自引率

2.80%

发文量

159

审稿时长

24 days

期刊介绍： Clinical Lung Cancer is a peer-reviewed bimonthly journal that publishes original articles describing various aspects of clinical and translational research of lung cancer. Clinical Lung Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of lung cancer. The main emphasis is on recent scientific developments in all areas related to lung cancer. Specific areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.