Pimarane diterpenoids：来源、结构和生物活性。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2024-11-13 DOI:10.1080/14786419.2024.2426071

Haiqiang Zhang, Meng Li, Ayi Lvha, Shengming Zhang

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引用次数: 0

摘要

皮马兰二萜是一类广泛存在的次级代谢产物，在几十种不同科的植物物种和其他分类群的生物中都有发现。根据手性中心的不同，皮马兰二萜可分为四种类型，包括皮马兰、异皮马兰、ent-皮马兰和ent-异皮马兰。同时，这些化合物具有多种药理活性，如细胞毒性、抗炎和抗菌活性。由于其显著的结构和生物活性，这些物质近年来备受关注。本综述全面介绍了 2000 年至 2023 年期间发现的皮马兰二萜的结构多样性（368 种结构，117 篇参考文献）和生物活性。

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Pimarane diterpenoids: sources, structures and biological activities.

The pimarane diterpenoids, a widespread class of secondary metabolites, have been found in several dozens of plant species from various families and in organisms from other taxonomic groups. According to the different chiral centres, pimarane diterpenes can be divided into four types, including pimarane, isopimarane, ent-pimarane, and ent-isopimarane. Meanwhile, these compounds possessed many pharmacological activities, such as cytotoxic, anti-inflammatory, and antibacterial activities. Due to their notable structure and biological activities these substances have attracted interest in recent years. A comprehensive account of the structural diversity (368 structures, 117 references) and biological activities of pimarane diterpenes discovered from 2000 until 2023 is given in this review.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.