SARS-CoV-2 感染对呼吸道和肠道微生物组稳定性的影响:对长期住院的 COVID-19 患者进行的元基因组研究。

IF 7.8 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY npj Biofilms and Microbiomes Pub Date : 2024-11-13 DOI:10.1038/s41522-024-00596-4
Zhengtu Li, Jing Chen, Yinhu Li, Linghua Li, Yangqing Zhan, Jiasheng Yang, Huiqin Wu, Shaoqiang Li, Xiaoneng Mo, Xidong Wang, Yiqun Mi, Xi Zhou, Yongming Li, Jun Wang, Yuanxiang Li, Ruilin Sun, Weiping Cai, Feng Ye
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引用次数: 0

摘要

在冠状病毒病 2019(COVID-19)大流行期间,微生态学的探索对于阐明复杂的感染机制和患者的康复至关重要。为了解读肠道和呼吸道微生物之间的相互作用,我们收集了 COVID-19 患者的痰拭子、咽拭子和粪便,并探索了肠道和呼吸道微生物之间的相互迁移。利用新一代测序(NGS)技术,我们研究了两名重症 COVID-19 患者住院期间肠道和呼吸道微生物相互迁移的情况。值得注意的是,我们观察到一名携带分枝杆菌的患者加速恢复了微生态平衡。对 32 名健康对照组和 110 名不同病情严重程度的 COVID-19 患者进行的比较分析显示,COVID-19 患者呼吸道和肠道中栖息的主要微生物发生了变化。在这些变化中,肠道酵母菌(BV)被认为是一种值得注意的微生物,在严重的 COVID-19 患者中表现出明显的富集。当 BV 高度富集时,可抑制大肠杆菌/肠球菌的过渡生长,间接防止唾液链球菌的过度生长,并维持肺/肠微生态的稳定。总之,本研究阐明了 COVID-19 患者肠道和呼吸道之间微生物的双向相互迁移。这些发现有望为 COVID-19 的治疗和管理提供新思路,同时强调微生态在传染病中的重要作用。然而,要想更深入地了解微生物迁移的机制,还需要对 BV 在感染恢复过程中的作用进行系统研究。
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Impact of SARS-CoV-2 infection on respiratory and gut microbiome stability: a metagenomic investigation in long-term-hospitalized COVID-19 patients.

During the coronavirus disease 2019 (COVID-19) pandemic, the exploration of microecology has been essential for elucidating the intricacies of infection mechanisms and the recovery of afflicted individuals. To decipher the interplay of microorganisms between the intestinal and respiratory tracts, we collected sputum and throat swabs and feces from COVID-19 patients and explored the mutual migration among intestinal and respiratory microorganisms. Using next-generation sequencing (NGS) technology, we investigated intestinal and respiratory microorganism intermigration in two patients with severe COVID-19 during their hospitalization. Notably, we observed an expedited recovery of microecological equilibrium in one patient harboring Mycobacterium avium. Comparative analyses between 32 healthy controls and 110 COVID-19 patients with different disease severities revealed alterations in predominant microorganisms inhabiting the respiratory and intestinal tracts of COVID-19 patients. Among the alterations, intestinal Bacteroides vulgatus (BV) was identified as a noteworthy microorganism that exhibited marked enrichment in patients with severe COVID-19. BV, when highly abundant, may inhibit the transitional growth of Escherichia coli/Enterococcus, indirectly prevent the overgrowth of salivary streptococci, and maintain lung/intestinal microecology stability. In summary, this study elucidates the bidirectional microbial intermigration between the intestinal and respiratory tracts in COVID-19 patients. These findings are expected to provide new ideas for the treatment and management of COVID-19, underscoring the essential role of microecology in infectious diseases. Nevertheless, a systematic study of the roles of BV in recovery from infection is required to gain a deeper understanding of the mechanisms of microbial migration.

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来源期刊
npj Biofilms and Microbiomes
npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology
CiteScore
12.10
自引率
3.30%
发文量
91
审稿时长
9 weeks
期刊介绍: npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.
期刊最新文献
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