Ana Rosa Barrio, Mariano González-Pérez, Pedro Arriola-Villalobos, Beatriz Antona
{"title":"ICP 泪道镜测量泪液半月板高度和无创破裂时间的会内重复性和观察者间重复性。","authors":"Ana Rosa Barrio, Mariano González-Pérez, Pedro Arriola-Villalobos, Beatriz Antona","doi":"10.1016/j.clae.2024.102333","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To examine intrasession repeatability and interobserver reproducibility of tear meniscus height (TMH) and non-invasive tear breakup time (NIBUT) measurements provided by ICP Tearscope, and their agreement with Keratograph 5 M measurements in persons with and without dry eye.</p><p><strong>Methods: </strong>Participants were 48 individuals with dry eye disease (DED) and 44 healthy controls. To determine intrasession repeatability, two consecutive TMH and NIBUT measurements were carried out by a single experienced examiner using ICP Tearscope. For interobserver reproducibility, a second masked investigator measured TMH and NIBUT on the first image and video captured by the examiner. Keratograph 5 M measurements of both variables were carried out by the same examiner. Repeatability and reproducibility were evaluated through within-subject standard deviation (Sw), coefficient of variation (CoV), intraclass correlation coefficient (ICC) and Bland-Altman plots (bias and limits of agreement (LoA)).</p><p><strong>Results: </strong>The TMH measurement with ICP Tearscope showed both, a moderate intrasession repeatability (Sw = 0.045, CoV < 19.82 %, ICC > 0.684) and interobserver reproducibility (Sw = 0.032, CoV < 14.09 %, ICC > 0.926). The NIBUT measurement showed worse intrasession repeatability in the DED group (CoV = 27.53 %) than in the Control group (CoV = 13.31 %). Even though similar Sw, LoA and ICC values were observed in both groups (Sw = 2.55 s and 2.34 s; LoA = -6.60 to 5.18 s and -4.82 to 6.51 s, Control and DED respectively, ICCs > 0.95). Interobserver reproducibility indicated a moderate amount of variability with CoV ≤ 15.01 % recorded in both groups. Agreement between the two devices was poor. Limits of agreement were not clinically acceptable for TMH (LoA = -0.19 to 0.14 mm and -0.16 to 0.13 mm, Control and DED, respectively) and for NIBUT (LoA = -12.74 to 14.08 s and -12.19 to 12.87 s, Control and DED, respectively).</p><p><strong>Conclusions: </strong>ICP Tearscope provides TMH and NIBUT measurements that show weak repeatability and moderate interobserver reproducibility. This device is not interchangeable with the Keratograph 5 M.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102333"},"PeriodicalIF":4.1000,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Intrasession repeatability and interobserver reproducibility of ICP Tearscope measurements of tear meniscus height and non-invasive breakup time.\",\"authors\":\"Ana Rosa Barrio, Mariano González-Pérez, Pedro Arriola-Villalobos, Beatriz Antona\",\"doi\":\"10.1016/j.clae.2024.102333\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To examine intrasession repeatability and interobserver reproducibility of tear meniscus height (TMH) and non-invasive tear breakup time (NIBUT) measurements provided by ICP Tearscope, and their agreement with Keratograph 5 M measurements in persons with and without dry eye.</p><p><strong>Methods: </strong>Participants were 48 individuals with dry eye disease (DED) and 44 healthy controls. To determine intrasession repeatability, two consecutive TMH and NIBUT measurements were carried out by a single experienced examiner using ICP Tearscope. For interobserver reproducibility, a second masked investigator measured TMH and NIBUT on the first image and video captured by the examiner. Keratograph 5 M measurements of both variables were carried out by the same examiner. Repeatability and reproducibility were evaluated through within-subject standard deviation (Sw), coefficient of variation (CoV), intraclass correlation coefficient (ICC) and Bland-Altman plots (bias and limits of agreement (LoA)).</p><p><strong>Results: </strong>The TMH measurement with ICP Tearscope showed both, a moderate intrasession repeatability (Sw = 0.045, CoV < 19.82 %, ICC > 0.684) and interobserver reproducibility (Sw = 0.032, CoV < 14.09 %, ICC > 0.926). The NIBUT measurement showed worse intrasession repeatability in the DED group (CoV = 27.53 %) than in the Control group (CoV = 13.31 %). Even though similar Sw, LoA and ICC values were observed in both groups (Sw = 2.55 s and 2.34 s; LoA = -6.60 to 5.18 s and -4.82 to 6.51 s, Control and DED respectively, ICCs > 0.95). Interobserver reproducibility indicated a moderate amount of variability with CoV ≤ 15.01 % recorded in both groups. Agreement between the two devices was poor. Limits of agreement were not clinically acceptable for TMH (LoA = -0.19 to 0.14 mm and -0.16 to 0.13 mm, Control and DED, respectively) and for NIBUT (LoA = -12.74 to 14.08 s and -12.19 to 12.87 s, Control and DED, respectively).</p><p><strong>Conclusions: </strong>ICP Tearscope provides TMH and NIBUT measurements that show weak repeatability and moderate interobserver reproducibility. This device is not interchangeable with the Keratograph 5 M.</p>\",\"PeriodicalId\":49087,\"journal\":{\"name\":\"Contact Lens & Anterior Eye\",\"volume\":\" \",\"pages\":\"102333\"},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2024-11-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Contact Lens & Anterior Eye\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.clae.2024.102333\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Contact Lens & Anterior Eye","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.clae.2024.102333","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Intrasession repeatability and interobserver reproducibility of ICP Tearscope measurements of tear meniscus height and non-invasive breakup time.
Purpose: To examine intrasession repeatability and interobserver reproducibility of tear meniscus height (TMH) and non-invasive tear breakup time (NIBUT) measurements provided by ICP Tearscope, and their agreement with Keratograph 5 M measurements in persons with and without dry eye.
Methods: Participants were 48 individuals with dry eye disease (DED) and 44 healthy controls. To determine intrasession repeatability, two consecutive TMH and NIBUT measurements were carried out by a single experienced examiner using ICP Tearscope. For interobserver reproducibility, a second masked investigator measured TMH and NIBUT on the first image and video captured by the examiner. Keratograph 5 M measurements of both variables were carried out by the same examiner. Repeatability and reproducibility were evaluated through within-subject standard deviation (Sw), coefficient of variation (CoV), intraclass correlation coefficient (ICC) and Bland-Altman plots (bias and limits of agreement (LoA)).
Results: The TMH measurement with ICP Tearscope showed both, a moderate intrasession repeatability (Sw = 0.045, CoV < 19.82 %, ICC > 0.684) and interobserver reproducibility (Sw = 0.032, CoV < 14.09 %, ICC > 0.926). The NIBUT measurement showed worse intrasession repeatability in the DED group (CoV = 27.53 %) than in the Control group (CoV = 13.31 %). Even though similar Sw, LoA and ICC values were observed in both groups (Sw = 2.55 s and 2.34 s; LoA = -6.60 to 5.18 s and -4.82 to 6.51 s, Control and DED respectively, ICCs > 0.95). Interobserver reproducibility indicated a moderate amount of variability with CoV ≤ 15.01 % recorded in both groups. Agreement between the two devices was poor. Limits of agreement were not clinically acceptable for TMH (LoA = -0.19 to 0.14 mm and -0.16 to 0.13 mm, Control and DED, respectively) and for NIBUT (LoA = -12.74 to 14.08 s and -12.19 to 12.87 s, Control and DED, respectively).
Conclusions: ICP Tearscope provides TMH and NIBUT measurements that show weak repeatability and moderate interobserver reproducibility. This device is not interchangeable with the Keratograph 5 M.
期刊介绍:
Contact Lens & Anterior Eye is a research-based journal covering all aspects of contact lens theory and practice, including original articles on invention and innovations, as well as the regular features of: Case Reports; Literary Reviews; Editorials; Instrumentation and Techniques and Dates of Professional Meetings.