TEMPO 介导的交叉脱氢偶联合成双(吲哚基)甲烷

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC Asian Journal of Organic Chemistry Pub Date : 2024-11-18 DOI:10.1002/ajoc.202400484

You-Qiang Guo, Long Liang, Zhen-Yu Wang, Xiang Wu, You-Gui Li

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引用次数: 0

摘要

通过对位甲酚衍生物的 C(sp3)-H与吲哚的 C(sp2)-H之间的交叉脱氢偶联，开发了一种 TEMPO 氧化法合成双(吲哚基)甲烷衍生物，在水溶液条件下产量适中。这种方法在避免预官能化、使用水作为溶剂和容忍各种官能团方面具有显著优势。

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TEMPO‐Mediated Cross‐Dehydrogenative Coupling for the Synthesis of Bis(indolyl)methanes

A TEMPO‐oxidized method has been developed for the synthesis of bis(indolyl)‐methane derivatives by the cross‐dehydrogenative coupling between C(sp3)–H of para‐cresol derivatives and C(sp2)‐H of indoles in moderate yields under aqueous conditions. This approach has significant advantages in avoiding prefunctionalization, using water as the solvent and tolerating various functional groups.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.