Perspectives on materials: Reality and potential of epigenetic drug nano-delivery

Epigenetic drugs have been used in the treatment of many diseases. Unfortunately, however, epigenetic drugs are not targeted, which makes the action of epigenetic drugs often systemic. This systemic epigenetic alteration can lead to a host of unwanted side effects. To improve delivery targeting and enhance the efficacy of drugs, the application of novel drug carriers in the field of epigenetic drug delivery becomes very important. We summarize the types of materials that have been used in the field of epigenetic drug delivery, such as liposomes, micelles, inorganic materials, framework materials, and so on (mainly in cancer therapy). We also describe some of the biocompatible or condition-responsive modifications commonly used in the field of drug nano-delivery based on the properties of different materials. Finally, we also draw inspiration from other drug delivery materials and reveal more materials that are still not used for epigenetic drug delivery, such as HOFs, Janus particles, molecular cage-like materials, etc., and discuss the current challenges and the way forward, which will provide more ideas for researchers.