Casandra I. Montoro , Pilar Ruiz-Medina , Stefan Duschek , Nicolás Gutiérrez-Palma , Gustavo A. Reyes del Paso
{"title":"DLPFC上的双侧tDCS可增强气压感受器反射灵敏度并抑制与血压相关的低痛感","authors":"Casandra I. Montoro , Pilar Ruiz-Medina , Stefan Duschek , Nicolás Gutiérrez-Palma , Gustavo A. Reyes del Paso","doi":"10.1016/j.clinph.2024.11.011","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated the impact of transcranial direct stimulation (tDCS) on pain perception, baroreflex sensitivity (BRS), and blood pressure (BP)-related hypoalgesia.</div></div><div><h3>Method</h3><div>Fifty-eight healthy participants were randomized to receive 1) bi-hemispheric tDCS over the dorsolateral prefrontal cortex (DLPFC) at 2 mA for 20 min, or 2) non-stimulation (Sham). Pain measures (threshold, tolerance, intensity and unpleasantness), emotional state (anxiety and mood), continuous BP, and electrocardiogram (ECG) data were recorded before, during, and after stimulation.</div></div><div><h3>Results</h3><div>tDCS stimulation was followed by increases in BRS, pain intensity and unpleasantness. Anxiety decreased in the Sham group, but not in the tDCS group. Positive correlations between BP and pain threshold and tolerance before stimulation were observed. These remained during stimulation in the Sham group, but not in the tDCS group. Moreover, negative associations between BRS and BP only persisted in the Sham group.</div></div><div><h3>Discussion</h3><div>The results suggest that bilateral tDCS over the DLPFC enhances BRS and modulates pain perception and BP-related mechanisms. tDCS increases pain perception by inhibiting BP-related hypoalgesia and preventing habituation of anxiety.</div></div><div><h3>Significance</h3><div>Low BRS is a powerful prognostic factor of cardiovascular disease, such that its increase via tDCS may be a new therapeutic strategy for cardiovascular health promotion.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 11-22"},"PeriodicalIF":3.7000,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Bilateral tDCS over the DLPFC enhances baroreceptor reflex sensitivity and inhibits blood pressure-related hypoalgesia\",\"authors\":\"Casandra I. Montoro , Pilar Ruiz-Medina , Stefan Duschek , Nicolás Gutiérrez-Palma , Gustavo A. Reyes del Paso\",\"doi\":\"10.1016/j.clinph.2024.11.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>This study investigated the impact of transcranial direct stimulation (tDCS) on pain perception, baroreflex sensitivity (BRS), and blood pressure (BP)-related hypoalgesia.</div></div><div><h3>Method</h3><div>Fifty-eight healthy participants were randomized to receive 1) bi-hemispheric tDCS over the dorsolateral prefrontal cortex (DLPFC) at 2 mA for 20 min, or 2) non-stimulation (Sham). Pain measures (threshold, tolerance, intensity and unpleasantness), emotional state (anxiety and mood), continuous BP, and electrocardiogram (ECG) data were recorded before, during, and after stimulation.</div></div><div><h3>Results</h3><div>tDCS stimulation was followed by increases in BRS, pain intensity and unpleasantness. Anxiety decreased in the Sham group, but not in the tDCS group. Positive correlations between BP and pain threshold and tolerance before stimulation were observed. These remained during stimulation in the Sham group, but not in the tDCS group. Moreover, negative associations between BRS and BP only persisted in the Sham group.</div></div><div><h3>Discussion</h3><div>The results suggest that bilateral tDCS over the DLPFC enhances BRS and modulates pain perception and BP-related mechanisms. tDCS increases pain perception by inhibiting BP-related hypoalgesia and preventing habituation of anxiety.</div></div><div><h3>Significance</h3><div>Low BRS is a powerful prognostic factor of cardiovascular disease, such that its increase via tDCS may be a new therapeutic strategy for cardiovascular health promotion.</div></div>\",\"PeriodicalId\":10671,\"journal\":{\"name\":\"Clinical Neurophysiology\",\"volume\":\"169 \",\"pages\":\"Pages 11-22\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-11-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Neurophysiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S138824572400333X\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Neurophysiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S138824572400333X","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Bilateral tDCS over the DLPFC enhances baroreceptor reflex sensitivity and inhibits blood pressure-related hypoalgesia
Objective
This study investigated the impact of transcranial direct stimulation (tDCS) on pain perception, baroreflex sensitivity (BRS), and blood pressure (BP)-related hypoalgesia.
Method
Fifty-eight healthy participants were randomized to receive 1) bi-hemispheric tDCS over the dorsolateral prefrontal cortex (DLPFC) at 2 mA for 20 min, or 2) non-stimulation (Sham). Pain measures (threshold, tolerance, intensity and unpleasantness), emotional state (anxiety and mood), continuous BP, and electrocardiogram (ECG) data were recorded before, during, and after stimulation.
Results
tDCS stimulation was followed by increases in BRS, pain intensity and unpleasantness. Anxiety decreased in the Sham group, but not in the tDCS group. Positive correlations between BP and pain threshold and tolerance before stimulation were observed. These remained during stimulation in the Sham group, but not in the tDCS group. Moreover, negative associations between BRS and BP only persisted in the Sham group.
Discussion
The results suggest that bilateral tDCS over the DLPFC enhances BRS and modulates pain perception and BP-related mechanisms. tDCS increases pain perception by inhibiting BP-related hypoalgesia and preventing habituation of anxiety.
Significance
Low BRS is a powerful prognostic factor of cardiovascular disease, such that its increase via tDCS may be a new therapeutic strategy for cardiovascular health promotion.
期刊介绍：
As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology.
Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.
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