{"title":"特立氟胺在超临界二氧化碳中的溶解度及助溶剂研究","authors":"Mahshid Askarizadeh , Nadia Esfandiari , Bizhan Honarvar , Seyed Ali Sajadian , Amin Azdarpour","doi":"10.1016/j.fluid.2024.114284","DOIUrl":null,"url":null,"abstract":"<div><div>The solubility of Teriflunomide in supercritical CO<sub>2</sub> at 338, 328, 318, and 308 K temperatures was investigated with and without a Co-solvent. Ethanol was also tested as a Co-solvent. Semi-empirical and empirical methods were used to model the data obtained from the experiments. In both the binary and ternary systems, Teriflunomide's solubility values ranged from 0.54 × 10<sup>-4</sup> to 0.64 × 10<sup>-3</sup> and 0.705 × 10<sup>-3</sup> to 2.78 × 10<sup>-3</sup>, respectively. The solubility was additionally examined using the PR-EoS along with the vdW2 mixing rule for both systems. Teriflunomide's solubility was considerably enhanced by the addition of ethanol, according to the findings. The highest solubility of Teriflunomide was observed in the Teriflunomide -Ethanol- CO<sub>2</sub> system at 338 K and 12 MPa, which was about 13.99 times greater than its solubility in supercritical carbon dioxide alone under the same conditions. The best correlation with AARD% and AIC<sub>c</sub> for binary and ternary methods, respectively, was demonstrated by the models put out by Jouyban <em>et al</em>. and the Sodeifian-Sajadian models.</div></div>","PeriodicalId":12170,"journal":{"name":"Fluid Phase Equilibria","volume":"590 ","pages":"Article 114284"},"PeriodicalIF":2.8000,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Solubility of teriflunomide in supercritical carbon dioxide and co-solvent investigation\",\"authors\":\"Mahshid Askarizadeh , Nadia Esfandiari , Bizhan Honarvar , Seyed Ali Sajadian , Amin Azdarpour\",\"doi\":\"10.1016/j.fluid.2024.114284\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The solubility of Teriflunomide in supercritical CO<sub>2</sub> at 338, 328, 318, and 308 K temperatures was investigated with and without a Co-solvent. Ethanol was also tested as a Co-solvent. Semi-empirical and empirical methods were used to model the data obtained from the experiments. In both the binary and ternary systems, Teriflunomide's solubility values ranged from 0.54 × 10<sup>-4</sup> to 0.64 × 10<sup>-3</sup> and 0.705 × 10<sup>-3</sup> to 2.78 × 10<sup>-3</sup>, respectively. The solubility was additionally examined using the PR-EoS along with the vdW2 mixing rule for both systems. Teriflunomide's solubility was considerably enhanced by the addition of ethanol, according to the findings. The highest solubility of Teriflunomide was observed in the Teriflunomide -Ethanol- CO<sub>2</sub> system at 338 K and 12 MPa, which was about 13.99 times greater than its solubility in supercritical carbon dioxide alone under the same conditions. The best correlation with AARD% and AIC<sub>c</sub> for binary and ternary methods, respectively, was demonstrated by the models put out by Jouyban <em>et al</em>. and the Sodeifian-Sajadian models.</div></div>\",\"PeriodicalId\":12170,\"journal\":{\"name\":\"Fluid Phase Equilibria\",\"volume\":\"590 \",\"pages\":\"Article 114284\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-11-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Fluid Phase Equilibria\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0378381224002590\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fluid Phase Equilibria","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0378381224002590","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Solubility of teriflunomide in supercritical carbon dioxide and co-solvent investigation
The solubility of Teriflunomide in supercritical CO2 at 338, 328, 318, and 308 K temperatures was investigated with and without a Co-solvent. Ethanol was also tested as a Co-solvent. Semi-empirical and empirical methods were used to model the data obtained from the experiments. In both the binary and ternary systems, Teriflunomide's solubility values ranged from 0.54 × 10-4 to 0.64 × 10-3 and 0.705 × 10-3 to 2.78 × 10-3, respectively. The solubility was additionally examined using the PR-EoS along with the vdW2 mixing rule for both systems. Teriflunomide's solubility was considerably enhanced by the addition of ethanol, according to the findings. The highest solubility of Teriflunomide was observed in the Teriflunomide -Ethanol- CO2 system at 338 K and 12 MPa, which was about 13.99 times greater than its solubility in supercritical carbon dioxide alone under the same conditions. The best correlation with AARD% and AICc for binary and ternary methods, respectively, was demonstrated by the models put out by Jouyban et al. and the Sodeifian-Sajadian models.
期刊介绍：
Fluid Phase Equilibria publishes high-quality papers dealing with experimental, theoretical, and applied research related to equilibrium and transport properties of fluids, solids, and interfaces. Subjects of interest include physical/phase and chemical equilibria; equilibrium and nonequilibrium thermophysical properties; fundamental thermodynamic relations; and stability. The systems central to the journal include pure substances and mixtures of organic and inorganic materials, including polymers, biochemicals, and surfactants with sufficient characterization of composition and purity for the results to be reproduced. Alloys are of interest only when thermodynamic studies are included, purely material studies will not be considered. In all cases, authors are expected to provide physical or chemical interpretations of the results.
Experimental research can include measurements under all conditions of temperature, pressure, and composition, including critical and supercritical. Measurements are to be associated with systems and conditions of fundamental or applied interest, and may not be only a collection of routine data, such as physical property or solubility measurements at limited pressures and temperatures close to ambient, or surfactant studies focussed strictly on micellisation or micelle structure. Papers reporting common data must be accompanied by new physical insights and/or contemporary or new theory or techniques.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
