探索多囊卵巢综合征中的乙酰化相关基因标记:利用机器学习深入了解发病机制和诊断潜力。

IF 2 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Gynecological Endocrinology Pub Date : 2024-12-01 Epub Date: 2024-11-25 DOI:10.1080/09513590.2024.2427202
Jiqing Wang, Yuqing Wang, Shanshan Li, Xiaoqin Fang, Chaoyue Zhang, Zuqing Wang, Yi Zheng, Hanzhi Deng, Shifen Xu, Yiqun Mi
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引用次数: 0

摘要

目的:多囊卵巢综合征(PCOS多囊卵巢综合征(PCOS)是导致女性月经不调和不孕的一个普遍原因,影响着女性的生活质量。尽管研究取得了进展,但目前对多囊卵巢综合征发病机制和治疗的了解仍然有限。本研究利用基于机器学习的数据挖掘来识别与多囊卵巢综合征相关的乙酰化相关遗传标记,旨在提高诊断精度和治疗效果:方法:采用先进的机器学习技术提高关键基因识别的精确度,并揭示其生物学机制。在独立数据集(GSE48301)上的验证证实了这些基因的诊断价值,并通过 ROC 曲线和多囊卵巢综合征风险预测提名图进行了评估。通过聚类、免疫环境和基因网络分析,进一步研究了多囊卵巢综合症中乙酰化相关基因调控的分子机制:结果:我们的分析确定了 15 个在多囊卵巢综合征中差异表达的关键乙酰化调控基因,其中包括与多囊卵巢综合征发病机制相关的 SGF29、NOL6、KLF15 和 INO80D。对训练数据集和验证数据集进行的 ROC 曲线分析证实了该模型具有很高的诊断准确性。此外,这些基因还与免疫细胞浸润有关,有助于深入了解多囊卵巢综合症的炎症方面:结论:已发现的乙酰化基因标记为了解多囊卵巢综合症的分子机制提供了新的视角,有望促进精确诊断和治疗策略的发展。
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Exploring acetylation-related gene markers in polycystic ovary syndrome: insights into pathogenesis and diagnostic potential using machine learning.

Objective: Polycystic ovary syndrome (PCOS) is a prevalent cause of menstrual irregularities and infertility in women, impacting quality of life. Despite advancements, current understanding of PCOS pathogenesis and treatment remains limited. This study uses machine learning-based data mining to identify acetylation-related genetic markers associated with PCOS, aiming to enhance diagnostic precision and therapeutic efficacy.

Methods: Advanced machine learning techniques were used to improve the precision of key gene identification and reveal their biological mechanisms. Validation on an independent dataset (GSE48301) confirmed their diagnostic value, assessed through ROC curves and nomograms for PCOS risk prediction. Molecular mechanisms of acetylation-related gene regulation in PCOS were further examined through clustering, immune-environmental, and gene network analyses.

Results: Our analysis identified 15 key acetylation-regulated genes differentially expressed in PCOS, including SGF29, NOL6, KLF15, and INO80D, which are relevant to PCOS pathogenesis. ROC curve analyses on training and validation datasets confirmed the model's high diagnostic accuracy. Additionally, these genes were associated with immune cell infiltration, offering insights into the inflammatory aspect of PCOS.

Conclusion: The identified acetylation gene markers offer novel insights into the molecular mechanisms underlying PCOS and hold promise for enhancing the development of precise diagnostic and therapeutic strategies.

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来源期刊
Gynecological Endocrinology
Gynecological Endocrinology 医学-妇产科学
CiteScore
4.40
自引率
5.00%
发文量
137
审稿时长
3-6 weeks
期刊介绍: Gynecological Endocrinology , the official journal of the International Society of Gynecological Endocrinology, covers all the experimental, clinical and therapeutic aspects of this ever more important discipline. It includes, amongst others, papers relating to the control and function of the different endocrine glands in females, the effects of reproductive events on the endocrine system, and the consequences of endocrine disorders on reproduction
期刊最新文献
Statement of Retraction: Combined metformin and clomiphene citrate versus highly purified FSH for ovulation induction in clomiphene-resistant PCOS women: a randomised controlled trial. Statement of Retraction: Minimal stimulation or clomiphene citrate as first-line therapy in women with polycystic ovary syndrome: a randomized controlled trial. Treatment of ovarian damage induced by chemotherapeutic drugs in female rats with G-CSF and platelet-rich plasma(PRP): an immunohistochemical study correlation with novel marker INSL-3. Update on the combination of myo-inositol/d-chiro-inositol for the treatment of polycystic ovary syndrome. Comparative effects of the antioxidant glutathione with metformin and Diane-35 on hormonal, metabolic, and inflammatory indicators in a DHEA-induced PCOS rat model.
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