Tian-Yi Xin, Zi-Lu Zhu, Liu-Jing Chen, Bin Han, Rui-Li Yang, Jie Shi
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引用次数: 0
摘要
目的：研究被诊断为C级牙周炎的患者在正畸治疗期间的免疫反应：我们的研究纳入了 7 名患有 C 级牙周炎的正畸患者，并测量了他们在正畸治疗前、对齐和矫治阶段以及细化和完成阶段的龈沟液和血浆中的炎症细胞因子水平。通过 KEGG 分析检测了牙周炎患者正畸过程中的关键信号通路：研究表明，正畸治疗对 C 级牙周炎患者的病情有很大改善，正畸治疗后大部分局部/全身炎症细胞因子均可减少。同时，正畸治疗可降低 C 级牙周炎患者 IFN-γ+ Th1 细胞的比例。通过 KEGG 分析发现，IL-17 信号通路和 TNF 信号通路在 C 级牙周炎患者的正畸治疗中密切相关（p 值 结论：正畸治疗能有效控制牙周炎患者的 IFN-γ+ Th1 细胞比例：正畸治疗可有效控制 C 级牙周炎患者的局部和系统炎症水平，IL-17A 和 TNF-α 是牙周炎患者正畸-牙周联合治疗的潜在的显著炎症标志物。
Profile of Inflammatory Cytokines in Gingival Crevicular Fluid and Plasma in Patients With Grade C Periodontitis During Orthodontic Treatment: A Longitudinal Case Series Report.
Aim: To examine the immune responses in patients diagnosed as grade C periodontitis during orthodontic treatment.
Materials and methods: Our study included seven orthodontic patients with grade C periodontitis and measured their levels of inflammatory cytokines in gingival crevicular fluid and plasma before orthodontic treatment, during the alignment and levelling phase, and during the detailing and finishing phase. The key signal pathways in the orthodontic process of patients with periodontitis were detected by KEGG analysis.
Results: Studies have shown that orthodontic treatment brings great improvement to patients with grade C periodontitis, and most of the local/systemic inflammatory cytokines can be reduced after orthodontic treatment. Simultaneously, orthodontic treatment can reduce the percentage of IFN-γ+ Th1 cells in patients with grade C periodontitis. Through KEGG analysis, the IL-17 signalling pathway and TNF signalling pathway are closely interrelated in the orthodontic treatment of patients diagnosed with grade C periodontitis (p-value < 0.001).
Conclusion: Orthodontic treatment can effectively control the local and system levels of inflammation in patients with grade C periodontitis, with IL-17A and TNF-α as potential distinctive inflammatory markers for orthodontic-periodontal combined treatment in individuals with periodontitis.
期刊介绍：
Orthodontics & Craniofacial Research - Genes, Growth and Development is published to serve its readers as an international forum for the presentation and critical discussion of issues pertinent to the advancement of the specialty of orthodontics and the evidence-based knowledge of craniofacial growth and development. This forum is based on scientifically supported information, but also includes minority and conflicting opinions.
The objective of the journal is to facilitate effective communication between the research community and practicing clinicians. Original papers of high scientific quality that report the findings of clinical trials, clinical epidemiology, and novel therapeutic or diagnostic approaches are appropriate submissions. Similarly, we welcome papers in genetics, developmental biology, syndromology, surgery, speech and hearing, and other biomedical disciplines related to clinical orthodontics and normal and abnormal craniofacial growth and development. In addition to original and basic research, the journal publishes concise reviews, case reports of substantial value, invited essays, letters, and announcements.
The journal is published quarterly. The review of submitted papers will be coordinated by the editor and members of the editorial board. It is policy to review manuscripts within 3 to 4 weeks of receipt and to publish within 3 to 6 months of acceptance.
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