Liting Wu, Feifei Chen, Miaomiao Chen, Yaping Hu, Ying Wang
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To evaluate the interaction of pre-pregnancy BMI and ART on PIH, the relative excess risk of interaction (RERI), the attributable proportion due to interaction (API), and synergy index (SI) were applied.</p><p><strong>Results: </strong>Of these 3,220,103 women, 302,789 [9.40% (95%CI: 9.37%-9.43%)] occurred PIH. Women with a pre-pregnancy BMI ≥25 kg/m<sup>2</sup> [odds ratio (OR)=2.06, 95% confidence interval (CI): 2.04-2.08] or using ART (OR = 1.43, 95%CI: 1.39-1.47) were related to a higher risk of PIH. There was a positive additive interaction of pre-pregnancy BMI and ART on the risk of PIH, with an interaction RERI, API, and SI of 0.20 (95%CI: 0.08-0.33), 0.07 (95%CI: 0.03-0.11), and 1.13 (95%CI: 1.05-1.21), respectively. Stratified analyses demonstrated that the positive additive interactions of pre-pregnancy BMI and ART on PIH were observed in women aged <35 years or ≥35 years and in women with unipara or multipara, whereas only in White women.</p><p><strong>Conclusion: </strong>A positive additive interaction of pre-pregnancy BMI and ART on the risk of PIH was found, with an interaction of 7%.</p>","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"40 1","pages":"2433136"},"PeriodicalIF":2.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Additive interaction of pre-pregnancy BMI and assisted reproductive technology on the risk of pregnancy-induced hypertension.\",\"authors\":\"Liting Wu, Feifei Chen, Miaomiao Chen, Yaping Hu, Ying Wang\",\"doi\":\"10.1080/09513590.2024.2433136\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To explore the combined effect of pre-pregnancy body mass index (BMI) and assisted reproductive technology (ART) on the risk of pregnancy-induced hypertension (PIH).</p><p><strong>Methods: </strong>This retrospective cohort study included 3,220,103 women with singleton pregnancies from the National Vital Statistics System database for 2021. The outcome was the occurrence of PIH. Logistic regression analyses were utilized to assess the association between pre-pregnancy BMI and ART and PIH. To evaluate the interaction of pre-pregnancy BMI and ART on PIH, the relative excess risk of interaction (RERI), the attributable proportion due to interaction (API), and synergy index (SI) were applied.</p><p><strong>Results: </strong>Of these 3,220,103 women, 302,789 [9.40% (95%CI: 9.37%-9.43%)] occurred PIH. Women with a pre-pregnancy BMI ≥25 kg/m<sup>2</sup> [odds ratio (OR)=2.06, 95% confidence interval (CI): 2.04-2.08] or using ART (OR = 1.43, 95%CI: 1.39-1.47) were related to a higher risk of PIH. There was a positive additive interaction of pre-pregnancy BMI and ART on the risk of PIH, with an interaction RERI, API, and SI of 0.20 (95%CI: 0.08-0.33), 0.07 (95%CI: 0.03-0.11), and 1.13 (95%CI: 1.05-1.21), respectively. 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引用次数: 0
摘要
目的：探讨孕前体重指数（BMI）与辅助生殖技术（ART）对妊娠高血压（PIH）风险的联合影响。方法：这项回顾性队列研究包括322,0103名来自2021年国家生命统计系统数据库的单胎妊娠妇女。结果为PIH的发生。采用Logistic回归分析评估孕前BMI与ART和PIH之间的关系。为了评价孕前BMI和ART对PIH的相互作用，采用相互作用的相对超额风险（relative excess risk of interaction, rei）、相互作用归因比例（attribution ratio To interaction， API）和协同作用指数（synergy index， SI）。结果：在这3,220,103名妇女中，302,789名[9.40% (95%CI: 9.37%-9.43%)]发生了PIH。孕前BMI≥25 kg/m2[比值比(OR)=2.06, 95%可信区间（CI）： 2.04-2.08]或使用ART （OR = 1.43, 95%CI: 1.39-1.47）的妇女发生PIH的风险较高。孕前BMI和ART对PIH的风险存在正的相互作用，相互作用的rei、API和SI分别为0.20 （95%CI: 0.08-0.33）、0.07 （95%CI: 0.03-0.11）和1.13 （95%CI: 1.05-1.21）。分层分析显示，孕前BMI与ART对老年妇女PIH的影响存在正的加性相互作用。结论：孕前BMI与ART对PIH的影响存在正的加性相互作用，相互作用为7%。
Additive interaction of pre-pregnancy BMI and assisted reproductive technology on the risk of pregnancy-induced hypertension.
Objective: To explore the combined effect of pre-pregnancy body mass index (BMI) and assisted reproductive technology (ART) on the risk of pregnancy-induced hypertension (PIH).
Methods: This retrospective cohort study included 3,220,103 women with singleton pregnancies from the National Vital Statistics System database for 2021. The outcome was the occurrence of PIH. Logistic regression analyses were utilized to assess the association between pre-pregnancy BMI and ART and PIH. To evaluate the interaction of pre-pregnancy BMI and ART on PIH, the relative excess risk of interaction (RERI), the attributable proportion due to interaction (API), and synergy index (SI) were applied.
Results: Of these 3,220,103 women, 302,789 [9.40% (95%CI: 9.37%-9.43%)] occurred PIH. Women with a pre-pregnancy BMI ≥25 kg/m2 [odds ratio (OR)=2.06, 95% confidence interval (CI): 2.04-2.08] or using ART (OR = 1.43, 95%CI: 1.39-1.47) were related to a higher risk of PIH. There was a positive additive interaction of pre-pregnancy BMI and ART on the risk of PIH, with an interaction RERI, API, and SI of 0.20 (95%CI: 0.08-0.33), 0.07 (95%CI: 0.03-0.11), and 1.13 (95%CI: 1.05-1.21), respectively. Stratified analyses demonstrated that the positive additive interactions of pre-pregnancy BMI and ART on PIH were observed in women aged <35 years or ≥35 years and in women with unipara or multipara, whereas only in White women.
Conclusion: A positive additive interaction of pre-pregnancy BMI and ART on the risk of PIH was found, with an interaction of 7%.
期刊介绍：
Gynecological Endocrinology , the official journal of the International Society of Gynecological Endocrinology, covers all the experimental, clinical and therapeutic aspects of this ever more important discipline. It includes, amongst others, papers relating to the control and function of the different endocrine glands in females, the effects of reproductive events on the endocrine system, and the consequences of endocrine disorders on reproduction
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