纳米脂质体两性霉素B对特比萘芬耐药印度毛癣菌的体外活性研究。

IF 2.3 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY International Microbiology Pub Date : 2024-11-30 DOI:10.1007/s10123-024-00617-4

Mohsen Nosratabadi, Javad Akhtari, Mahmoud Reza Jaafari, Zahra Yahyazadeh, Tahereh Shokohi, Iman Haghani, Pardis Farmani, Robab Ebrahimi Barough, Hamid Badali, Mahdi Abastabar

{"title":"纳米脂质体两性霉素B对特比萘芬耐药印度毛癣菌的体外活性研究。","authors":"Mohsen Nosratabadi, Javad Akhtari, Mahmoud Reza Jaafari, Zahra Yahyazadeh, Tahereh Shokohi, Iman Haghani, Pardis Farmani, Robab Ebrahimi Barough, Hamid Badali, Mahdi Abastabar","doi":"10.1007/s10123-024-00617-4","DOIUrl":null,"url":null,"abstract":"Background: The emergence of resistance in dermatophytes underscores the necessity for developing novel and alternative treatment options.Methods: The present study aimed to evaluate the in vitro activity of nanoliposomal amphotericin B against a large panel of terbinafine-resistant Trichophyton indotineae isolates. In vitro susceptibility testing of nanoliposomal amphotericin B and comparators against 50 clinical isolates of terbinafine-resistant T. indotineae strains was performed by broth microdilution according to the Clinical and Laboratory Standards Institute (CLSI) M38-A3 document.Results: The highest MIC90 and widest MIC range were found for terbinafine (4 and ≥ 4 µg/ml) followed by itraconazole (0.5 and 0.016-16 µg/ml). In contrast, the nanoliposomal amphotericin B and conventional amphotericin B exhibited low MIC90 (0.5 µg/ml) and MIC range (0.25-0.5 µg/ml).Conclusions: The study findings revealed that nanoliposomal amphotericin B might be a promising candidate against terbinafine-resistant strains of T. indotineae. However, further studies are required to pave the way for developing novel antifungal compounds to combat fungal resistance.","PeriodicalId":14318,"journal":{"name":"International Microbiology","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"In vitro activity of nanoliposomal amphotericin B against terbinafine-resistant Trichophyton indotineae isolates.\",\"authors\":\"Mohsen Nosratabadi, Javad Akhtari, Mahmoud Reza Jaafari, Zahra Yahyazadeh, Tahereh Shokohi, Iman Haghani, Pardis Farmani, Robab Ebrahimi Barough, Hamid Badali, Mahdi Abastabar\",\"doi\":\"10.1007/s10123-024-00617-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: The emergence of resistance in dermatophytes underscores the necessity for developing novel and alternative treatment options.Methods: The present study aimed to evaluate the in vitro activity of nanoliposomal amphotericin B against a large panel of terbinafine-resistant Trichophyton indotineae isolates. In vitro susceptibility testing of nanoliposomal amphotericin B and comparators against 50 clinical isolates of terbinafine-resistant T. indotineae strains was performed by broth microdilution according to the Clinical and Laboratory Standards Institute (CLSI) M38-A3 document.Results: The highest MIC90 and widest MIC range were found for terbinafine (4 and ≥ 4 µg/ml) followed by itraconazole (0.5 and 0.016-16 µg/ml). In contrast, the nanoliposomal amphotericin B and conventional amphotericin B exhibited low MIC90 (0.5 µg/ml) and MIC range (0.25-0.5 µg/ml).Conclusions: The study findings revealed that nanoliposomal amphotericin B might be a promising candidate against terbinafine-resistant strains of T. indotineae. However, further studies are required to pave the way for developing novel antifungal compounds to combat fungal resistance.\",\"PeriodicalId\":14318,\"journal\":{\"name\":\"International Microbiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-11-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Microbiology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1007/s10123-024-00617-4\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Microbiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s10123-024-00617-4","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

背景：皮肤真菌耐药的出现强调了开发新的替代治疗方案的必要性。方法：本研究旨在评价纳米脂质体两性霉素B对耐特比萘芬的吲哚毛癣菌的体外活性。采用肉汤微量稀释法，按照美国临床与实验室标准协会（CLSI） M38-A3文件进行纳米脂质体两性霉素B及比较物对50株耐特比萘芬临床分离株的体外药敏试验。结果：特比萘芬（4和≥4µg/ml）的MIC90最高，MIC范围最宽，其次是伊曲康唑（0.5和0.016 ~ 16µg/ml）。相比之下，纳米脂质体两性霉素B和常规两性霉素B的MIC90较低（0.5µg/ml）， MIC范围为0.25 ~ 0.5µg/ml。结论：研究结果表明，纳米脂质体两性霉素B可能是抗特比萘芬耐药菌株的有希望的候选药物。然而，需要进一步的研究为开发新的抗真菌化合物来对抗真菌耐药性铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

In vitro activity of nanoliposomal amphotericin B against terbinafine-resistant Trichophyton indotineae isolates.

Background: The emergence of resistance in dermatophytes underscores the necessity for developing novel and alternative treatment options.

Methods: The present study aimed to evaluate the in vitro activity of nanoliposomal amphotericin B against a large panel of terbinafine-resistant Trichophyton indotineae isolates. In vitro susceptibility testing of nanoliposomal amphotericin B and comparators against 50 clinical isolates of terbinafine-resistant T. indotineae strains was performed by broth microdilution according to the Clinical and Laboratory Standards Institute (CLSI) M38-A3 document.

Results: The highest MIC₉₀ and widest MIC range were found for terbinafine (4 and ≥ 4 µg/ml) followed by itraconazole (0.5 and 0.016-16 µg/ml). In contrast, the nanoliposomal amphotericin B and conventional amphotericin B exhibited low MIC₉₀ (0.5 µg/ml) and MIC range (0.25-0.5 µg/ml).

Conclusions: The study findings revealed that nanoliposomal amphotericin B might be a promising candidate against terbinafine-resistant strains of T. indotineae. However, further studies are required to pave the way for developing novel antifungal compounds to combat fungal resistance.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

International Microbiology 生物-生物工程与应用微生物

CiteScore

5.50

自引率

3.20%

发文量

审稿时长

3 months

期刊介绍： International Microbiology publishes information on basic and applied microbiology for a worldwide readership. The journal publishes articles and short reviews based on original research, articles about microbiologists and their work and questions related to the history and sociology of this science. Also offered are perspectives, opinion, book reviews and editorials. A distinguishing feature of International Microbiology is its broadening of the term microbiology to include eukaryotic microorganisms.