中性粒细胞的多样性及其在健康和疾病中的功能

IF 40.8 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Signal Transduction and Targeted Therapy Pub Date : 2024-12-06 DOI:10.1038/s41392-024-02049-y
Fengyuan Zhang, Yidan Xia, Jiayang Su, Fushi Quan, Hengzong Zhou, Qirong Li, Qiang Feng, Chao Lin, Dongxu Wang, Ziping Jiang
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引用次数: 0

摘要

中性粒细胞是最丰富的粒细胞类型,被广泛认为是急性炎症反应的关键贡献者之一。最初,中性粒细胞被认为是先天免疫系统的移动步兵,其任务是对入侵的病原体作出即时反应。然而,最近的研究表明,中性粒细胞是多功能细胞,能够调节各种生物过程并影响人类健康和疾病。细胞因子和其他活性介质通过激活中性粒细胞上的多个受体来调节中性粒细胞的功能活性,从而启动下游信号转导途径。中性粒细胞功能障碍和中性粒细胞稳态的破坏与许多疾病的发病机制有关,包括癌症和炎症性疾病,通常是由于细胞内信号传导异常引起的。本文综述了中性粒细胞生物学功能的综合研究,并结合近年来该领域的研究进展。此外,它还研究了中性粒细胞受体的生物学作用以及参与中性粒细胞活性调节的下游信号通路。中性粒细胞在许多人类疾病中的病理生理学和针对它们的新兴治疗方法也进行了阐述。这篇综述还指出了目前中性粒细胞研究领域的局限性,强调了需要进一步研究的关键知识空白。综上所述,本文旨在建立一个全面、多维的中性粒细胞调控模型,为临床应用和进一步研究提供新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Neutrophil diversity and function in health and disease

Neutrophils, the most abundant type of granulocyte, are widely recognized as one of the pivotal contributors to the acute inflammatory response. Initially, neutrophils were considered the mobile infantry of the innate immune system, tasked with the immediate response to invading pathogens. However, recent studies have demonstrated that neutrophils are versatile cells, capable of regulating various biological processes and impacting both human health and disease. Cytokines and other active mediators regulate the functional activity of neutrophils by activating multiple receptors on these cells, thereby initiating downstream signal transduction pathways. Dysfunctions in neutrophils and disruptions in neutrophil homeostasis have been implicated in the pathogenesis of numerous diseases, including cancer and inflammatory disorders, often due to aberrant intracellular signaling. This review provides a comprehensive synthesis of neutrophil biological functions, integrating recent advancements in this field. Moreover, it examines the biological roles of receptors on neutrophils and downstream signaling pathways involved in the regulation of neutrophil activity. The pathophysiology of neutrophils in numerous human diseases and emerging therapeutic approaches targeting them are also elaborated. This review also addresses the current limitations within the field of neutrophil research, highlighting critical gaps in knowledge that warrant further investigation. In summary, this review seeks to establish a comprehensive and multidimensional model of neutrophil regulation, providing new perspectives for potential clinical applications and further research.

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来源期刊
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
44.50
自引率
1.50%
发文量
384
审稿时长
5 weeks
期刊介绍: Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.
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