{"title":"基于荧光聚合物纳米颗粒的调节RELL1治疗结直肠癌的给药系统","authors":"Jie Feng, Yan Chu, Nuo Cheng, Qincong Pan","doi":"10.1007/s11051-024-06193-y","DOIUrl":null,"url":null,"abstract":"<div><p>Colorectal cancer, a common cancer affecting the colon or rectum, poses a significant global health risk, often leading to severe complications and mortality. The likelihood of developing colorectal cancer rises with age, with most cases occurring in individuals over 50. To investigate the role of RELL1 in colon cancer progression, we analyzed the colon adenoma dataset GSE41657 from the Gene Expression Omnibus (GEO) and identified RELL1 as a key target for this study. We developed an innovative drug-loaded polymer fluorescent nanoparticle system, PEG-CS-FITC, which combines chitosan (CS) nanoparticles, polyethylene glycol (PEG), and fluorescein isothiocyanate (FITC). This nanoparticle platform encapsulated compound CP1 and was designed to deliver a newly synthesized therapeutic compound, resulting in the composite nanoparticle PEG-CS-FITC@CP1@1. Through biological testing, we assessed the impact of PEG-CS-FITC@CP1@1 on RELL1 expression in colorectal cancer cells. These findings establish a foundation for developing targeted therapies for colorectal cancer.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"26 12","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Fluorescent polymer nanoparticle-based drug delivery system for treatment of colorectal cancer by modulating RELL1\",\"authors\":\"Jie Feng, Yan Chu, Nuo Cheng, Qincong Pan\",\"doi\":\"10.1007/s11051-024-06193-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Colorectal cancer, a common cancer affecting the colon or rectum, poses a significant global health risk, often leading to severe complications and mortality. The likelihood of developing colorectal cancer rises with age, with most cases occurring in individuals over 50. To investigate the role of RELL1 in colon cancer progression, we analyzed the colon adenoma dataset GSE41657 from the Gene Expression Omnibus (GEO) and identified RELL1 as a key target for this study. We developed an innovative drug-loaded polymer fluorescent nanoparticle system, PEG-CS-FITC, which combines chitosan (CS) nanoparticles, polyethylene glycol (PEG), and fluorescein isothiocyanate (FITC). This nanoparticle platform encapsulated compound CP1 and was designed to deliver a newly synthesized therapeutic compound, resulting in the composite nanoparticle PEG-CS-FITC@CP1@1. Through biological testing, we assessed the impact of PEG-CS-FITC@CP1@1 on RELL1 expression in colorectal cancer cells. These findings establish a foundation for developing targeted therapies for colorectal cancer.</p></div>\",\"PeriodicalId\":653,\"journal\":{\"name\":\"Journal of Nanoparticle Research\",\"volume\":\"26 12\",\"pages\":\"\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-12-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Nanoparticle Research\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11051-024-06193-y\",\"RegionNum\":4,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nanoparticle Research","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s11051-024-06193-y","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
摘要
结直肠癌是一种影响结肠或直肠的常见癌症，对全球健康构成重大风险，往往导致严重并发症和死亡。患结直肠癌的可能性随着年龄的增长而增加，大多数病例发生在50岁以上的人群中。为了研究RELL1在结肠癌进展中的作用，我们分析了来自Gene Expression Omnibus （GEO）的结肠腺瘤数据集GSE41657，并将RELL1确定为本研究的关键靶点。我们开发了一种创新的载药聚合物荧光纳米颗粒系统，PEG-CS-FITC，它结合了壳聚糖（CS）纳米颗粒、聚乙二醇（PEG）和异硫氰酸荧光素（FITC）。该纳米颗粒平台封装了化合物CP1，并设计用于递送新合成的治疗化合物，从而形成复合纳米颗粒PEG-CS-FITC@CP1@1。通过生物学测试，我们评估了PEG-CS-FITC@CP1@1对结直肠癌细胞中RELL1表达的影响。这些发现为开发结直肠癌的靶向治疗奠定了基础。
Fluorescent polymer nanoparticle-based drug delivery system for treatment of colorectal cancer by modulating RELL1
Colorectal cancer, a common cancer affecting the colon or rectum, poses a significant global health risk, often leading to severe complications and mortality. The likelihood of developing colorectal cancer rises with age, with most cases occurring in individuals over 50. To investigate the role of RELL1 in colon cancer progression, we analyzed the colon adenoma dataset GSE41657 from the Gene Expression Omnibus (GEO) and identified RELL1 as a key target for this study. We developed an innovative drug-loaded polymer fluorescent nanoparticle system, PEG-CS-FITC, which combines chitosan (CS) nanoparticles, polyethylene glycol (PEG), and fluorescein isothiocyanate (FITC). This nanoparticle platform encapsulated compound CP1 and was designed to deliver a newly synthesized therapeutic compound, resulting in the composite nanoparticle PEG-CS-FITC@CP1@1. Through biological testing, we assessed the impact of PEG-CS-FITC@CP1@1 on RELL1 expression in colorectal cancer cells. These findings establish a foundation for developing targeted therapies for colorectal cancer.
期刊介绍：
The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size.
Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology.
The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.
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