融合M2巨噬细胞和人脐带间充质干细胞的细胞外囊泡,靶向调节假体周围骨溶解中的巨噬细胞热凋亡。

IF 15.5 1区 医学 Q1 CELL BIOLOGY Journal of Extracellular Vesicles Pub Date : 2024-12-23 DOI:10.1002/jev2.70028
Qimeng Liu, Tianliang Ma, Zheyu Zhang, Jiangyu Nan, Guanzhi Liu, Yute Yang, Yihe Hu, Jie Xie
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引用次数: 0

摘要

预防和治疗假体无菌性松动的策略的发展是全球研究兴趣的一个关键领域。磨损颗粒引发的局部巨噬细胞凋亡在假体周围骨溶解和随后的松动中起关键作用。细胞外囊泡携带着亲本细胞的表面成分和调控分子,体现了这些祖细胞的细胞特性和生物学功能。为了精确抑制磨损颗粒诱导的局部巨噬细胞的焦亡,我们设计了融合M2巨噬细胞和人脐带间充质干细胞的细胞外囊泡(fEV)。这些fEV具有独特的靶向转运和免疫逃避能力,共同增强了治疗性细胞外囊泡的抗焦亡作用。我们的研究证明了feev对磨损颗粒引起的假体周围骨溶解具有针对性、显著的预防和治疗潜力,突出了其重要的临床意义和应用前景。这些发现表明,细胞外囊泡融合技术预示着基于靶向细胞外囊泡的药物传递系统的设计和开发的新范式。
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Fused extracellular vesicles from M2 macrophages and human umbilical cord mesenchymal stem cells for the targeted regulation of macrophage pyroptosis in periprosthetic osteolysis

The development of strategies for the prevention and treatment of aseptic loosening of prostheses stands as a critical area of global research interest. The pyroptosis of local macrophages triggered by wear particles plays a pivotal role in the onset of periprosthetic osteolysis and subsequent loosening. Extracellular vesicles, carrying the surface components and regulatory molecules of their parent cells, embody the cellular characteristics and biological functions of these progenitors. In a pioneering approach to precisely inhibit the pyroptosis of local macrophages induced by wear particles, we have engineered fused extracellular vesicles (fEV) from M2 macrophages and human umbilical cord mesenchymal stem cells. These fEV boast the distinctive capability for targeted transport and immune evasion, collectively enhancing the anti-pyroptosis effect of the therapeutic extracellular vesicles. Our research demonstrates the targeted, significant preventive and therapeutic potential of fEVs against periprosthetic osteolysis prompted by wear particles, highlighting its crucial clinical significance and application prospects. These findings suggest that extracellular vesicle fusion technology heralds a novel paradigm in the design and development of targeted extracellular vesicle-based drug delivery systems.

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来源期刊
Journal of Extracellular Vesicles
Journal of Extracellular Vesicles Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
27.30
自引率
4.40%
发文量
115
审稿时长
12 weeks
期刊介绍: The Journal of Extracellular Vesicles is an open access research publication that focuses on extracellular vesicles, including microvesicles, exosomes, ectosomes, and apoptotic bodies. It serves as the official journal of the International Society for Extracellular Vesicles and aims to facilitate the exchange of data, ideas, and information pertaining to the chemistry, biology, and applications of extracellular vesicles. The journal covers various aspects such as the cellular and molecular mechanisms of extracellular vesicles biogenesis, technological advancements in their isolation, quantification, and characterization, the role and function of extracellular vesicles in biology, stem cell-derived extracellular vesicles and their biology, as well as the application of extracellular vesicles for pharmacological, immunological, or genetic therapies. The Journal of Extracellular Vesicles is widely recognized and indexed by numerous services, including Biological Abstracts, BIOSIS Previews, Chemical Abstracts Service (CAS), Current Contents/Life Sciences, Directory of Open Access Journals (DOAJ), Journal Citation Reports/Science Edition, Google Scholar, ProQuest Natural Science Collection, ProQuest SciTech Collection, SciTech Premium Collection, PubMed Central/PubMed, Science Citation Index Expanded, ScienceOpen, and Scopus.
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