提高维生素D水平与降低死产发生率有关。

IF 1.6 4区 医学 Q4 ONCOLOGY Anticancer research Pub Date : 2025-01-01 DOI:10.21873/anticanres.17411
Pelle G Lindqvist, Mika Gissler
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引用次数: 0

摘要

背景/目的:两项前瞻性队列的回顾性研究显示,血浆维生素D水平低的妇女出生时窒息的几率增加了一倍,另一项研究报告死产的风险增加了四倍。目前尚不清楚这是否与日照不足或维生素D不足本身有关。我们的目的是评估这是否与维生素D水平有关。患者和方法:我们分析了1994年至2021年期间芬兰和瑞典所有孕妇的死产发生率与国家维生素D水平的关系(n > 430万)。由于50%的人口血浆维生素D含量低,芬兰在2003年实施了一项广泛的维生素D食品强化计划,由于效果不佳,2009年将其增加了一倍。2009年之后,10%的芬兰女性维生素D水平较低。死产发生率与使用95%置信区间交叉表的变化有关。结果:芬兰的死产发生率从2003年以前的4.1/ 1000下降到2004 - 2009年的3.4/ 1000,2009年以后下降到2.8/ 1000。与此同时,瑞典的死产率一直保持在3.9/ 1000,直到2018年芬兰食品强化计划在瑞典实施。此后,瑞典的死产发生率下降到3.2/ 1000。妊娠期肝内胆汁淤积(另一种与血浆维生素D水平低有关的缺氧妊娠并发症)的发生率没有下降。结论:在我们对国家维生素D食品强化的大型研究中,改善维生素D状态与较低的死产率呈剂量依赖性。
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Improved Vitamin D Status Is Associated With Lower Incidence of Stillbirth.

Background/aim: Two retrospective studies of prospective cohorts showed doubled odds of birth asphyxia among women with low plasma vitamin D levels, and another study reported a four-fold increased risk of stillbirth. It was not known whether this was related to low sun exposure or to insufficient vitamin D per se. We aimed to assess if it was due to vitamin D status.

Patients and methods: We analyzed the incidence of stillbirth in relation to national vitamin D status for all pregnancies in Finland and Sweden between 1994 and 2021 (n >4.3 million). Due to 50% of the population having low plasma vitamin D, Finland implemented an extensive vitamin D food fortification program in 2003 and doubled it in 2009 because of inadequate results. After 2009, 10% of Finnish women had low vitamin D levels. Stillbirth incidence was related to changes using cross-tabulation with 95% confidence intervals.

Results: The stillborn incidence in Finland decreased from 4.1/1,000 (prior to 2003), to 3.4/1,000 (2004 to 2009), and to 2.8/1,000 after 2009. In the meantime, the Swedish stillbirth rate remained constant at 3.9/1,000 until 2018, when the Finnish food fortification plan was implemented in Sweden. Thereafter, the Swedish stillbirth incidence dropped to 3.2/1,000. The rate of intrahepatic cholestasis of pregnancy, another hypoxic pregnancy complication related to low plasma vitamin D levels, did not drop.

Conclusion: In our large study of national vitamin D food fortification, improved vitamin D status was associated with a lower stillbirth rate in a dose-dependent manner.

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来源期刊
Anticancer research
Anticancer research 医学-肿瘤学
CiteScore
3.70
自引率
10.00%
发文量
566
审稿时长
2 months
期刊介绍: ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed. ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies). Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.
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