{"title":"提高维生素D水平与降低死产发生率有关。","authors":"Pelle G Lindqvist, Mika Gissler","doi":"10.21873/anticanres.17411","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/aim: </strong>Two retrospective studies of prospective cohorts showed doubled odds of birth asphyxia among women with low plasma vitamin D levels, and another study reported a four-fold increased risk of stillbirth. It was not known whether this was related to low sun exposure or to insufficient vitamin D per se. We aimed to assess if it was due to vitamin D status.</p><p><strong>Patients and methods: </strong>We analyzed the incidence of stillbirth in relation to national vitamin D status for all pregnancies in Finland and Sweden between 1994 and 2021 (n >4.3 million). Due to 50% of the population having low plasma vitamin D, Finland implemented an extensive vitamin D food fortification program in 2003 and doubled it in 2009 because of inadequate results. After 2009, 10% of Finnish women had low vitamin D levels. Stillbirth incidence was related to changes using cross-tabulation with 95% confidence intervals.</p><p><strong>Results: </strong>The stillborn incidence in Finland decreased from 4.1/1,000 (prior to 2003), to 3.4/1,000 (2004 to 2009), and to 2.8/1,000 after 2009. In the meantime, the Swedish stillbirth rate remained constant at 3.9/1,000 until 2018, when the Finnish food fortification plan was implemented in Sweden. Thereafter, the Swedish stillbirth incidence dropped to 3.2/1,000. The rate of intrahepatic cholestasis of pregnancy, another hypoxic pregnancy complication related to low plasma vitamin D levels, did not drop.</p><p><strong>Conclusion: </strong>In our large study of national vitamin D food fortification, improved vitamin D status was associated with a lower stillbirth rate in a dose-dependent manner.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 1","pages":"243-250"},"PeriodicalIF":1.6000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Improved Vitamin D Status Is Associated With Lower Incidence of Stillbirth.\",\"authors\":\"Pelle G Lindqvist, Mika Gissler\",\"doi\":\"10.21873/anticanres.17411\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background/aim: </strong>Two retrospective studies of prospective cohorts showed doubled odds of birth asphyxia among women with low plasma vitamin D levels, and another study reported a four-fold increased risk of stillbirth. It was not known whether this was related to low sun exposure or to insufficient vitamin D per se. We aimed to assess if it was due to vitamin D status.</p><p><strong>Patients and methods: </strong>We analyzed the incidence of stillbirth in relation to national vitamin D status for all pregnancies in Finland and Sweden between 1994 and 2021 (n >4.3 million). Due to 50% of the population having low plasma vitamin D, Finland implemented an extensive vitamin D food fortification program in 2003 and doubled it in 2009 because of inadequate results. After 2009, 10% of Finnish women had low vitamin D levels. Stillbirth incidence was related to changes using cross-tabulation with 95% confidence intervals.</p><p><strong>Results: </strong>The stillborn incidence in Finland decreased from 4.1/1,000 (prior to 2003), to 3.4/1,000 (2004 to 2009), and to 2.8/1,000 after 2009. In the meantime, the Swedish stillbirth rate remained constant at 3.9/1,000 until 2018, when the Finnish food fortification plan was implemented in Sweden. Thereafter, the Swedish stillbirth incidence dropped to 3.2/1,000. The rate of intrahepatic cholestasis of pregnancy, another hypoxic pregnancy complication related to low plasma vitamin D levels, did not drop.</p><p><strong>Conclusion: </strong>In our large study of national vitamin D food fortification, improved vitamin D status was associated with a lower stillbirth rate in a dose-dependent manner.</p>\",\"PeriodicalId\":8072,\"journal\":{\"name\":\"Anticancer research\",\"volume\":\"45 1\",\"pages\":\"243-250\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Anticancer research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.21873/anticanres.17411\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anticancer research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21873/anticanres.17411","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
Improved Vitamin D Status Is Associated With Lower Incidence of Stillbirth.
Background/aim: Two retrospective studies of prospective cohorts showed doubled odds of birth asphyxia among women with low plasma vitamin D levels, and another study reported a four-fold increased risk of stillbirth. It was not known whether this was related to low sun exposure or to insufficient vitamin D per se. We aimed to assess if it was due to vitamin D status.
Patients and methods: We analyzed the incidence of stillbirth in relation to national vitamin D status for all pregnancies in Finland and Sweden between 1994 and 2021 (n >4.3 million). Due to 50% of the population having low plasma vitamin D, Finland implemented an extensive vitamin D food fortification program in 2003 and doubled it in 2009 because of inadequate results. After 2009, 10% of Finnish women had low vitamin D levels. Stillbirth incidence was related to changes using cross-tabulation with 95% confidence intervals.
Results: The stillborn incidence in Finland decreased from 4.1/1,000 (prior to 2003), to 3.4/1,000 (2004 to 2009), and to 2.8/1,000 after 2009. In the meantime, the Swedish stillbirth rate remained constant at 3.9/1,000 until 2018, when the Finnish food fortification plan was implemented in Sweden. Thereafter, the Swedish stillbirth incidence dropped to 3.2/1,000. The rate of intrahepatic cholestasis of pregnancy, another hypoxic pregnancy complication related to low plasma vitamin D levels, did not drop.
Conclusion: In our large study of national vitamin D food fortification, improved vitamin D status was associated with a lower stillbirth rate in a dose-dependent manner.
期刊介绍:
ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed.
ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies).
Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.