{"title":"世界上沉默的杀手:黄曲霉菌株研究进展。","authors":"Yann Christie Sissinto Adjovi, Joli Prince Mintognissè Fossou, Ulrich Hilarion Ahehehinnou","doi":"10.1016/j.toxicon.2024.108225","DOIUrl":null,"url":null,"abstract":"<p><p>Filamentous fungi are recognized for their significance in food processing and antibiotic production, as well as their capacity to produce mycotoxins. Numerous secondary metabolites have been investigated, and their occurrence in foodstuffs, both in the field and during the storage of agricultural products, poses a substantial health risk to consumers. Several fungal species capable of producing mycotoxins have been documented. However, their presence suggests the potential occurrence of mycotoxins, of which only the most well-known are considered in health risk assessment, thus potentially underestimating the complex mixture to which consumers may be exposed. This review examines the range of secondary metabolites produced by Aspergillus species of the Flavi section found in agricultural products and foodstuffs. Known for their ability to produce aflatoxins, the presence of these fungi typically leads to the investigation of only aflatoxins, and possibly cyclopiazonic acid, in contaminated foods. This review elucidates the secondary metabolites produced by the Flavi section of Aspergillus and examines the associated hazards, to contribute to the assessment of the potential risk that the presence of these fungi in food products may represent.</p>","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":" ","pages":"108225"},"PeriodicalIF":2.6000,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A silent killer in the word: Review on Aspergillus flavus strains.\",\"authors\":\"Yann Christie Sissinto Adjovi, Joli Prince Mintognissè Fossou, Ulrich Hilarion Ahehehinnou\",\"doi\":\"10.1016/j.toxicon.2024.108225\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Filamentous fungi are recognized for their significance in food processing and antibiotic production, as well as their capacity to produce mycotoxins. Numerous secondary metabolites have been investigated, and their occurrence in foodstuffs, both in the field and during the storage of agricultural products, poses a substantial health risk to consumers. Several fungal species capable of producing mycotoxins have been documented. However, their presence suggests the potential occurrence of mycotoxins, of which only the most well-known are considered in health risk assessment, thus potentially underestimating the complex mixture to which consumers may be exposed. This review examines the range of secondary metabolites produced by Aspergillus species of the Flavi section found in agricultural products and foodstuffs. Known for their ability to produce aflatoxins, the presence of these fungi typically leads to the investigation of only aflatoxins, and possibly cyclopiazonic acid, in contaminated foods. This review elucidates the secondary metabolites produced by the Flavi section of Aspergillus and examines the associated hazards, to contribute to the assessment of the potential risk that the presence of these fungi in food products may represent.</p>\",\"PeriodicalId\":23289,\"journal\":{\"name\":\"Toxicon\",\"volume\":\" \",\"pages\":\"108225\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-01-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Toxicon\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.toxicon.2024.108225\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicon","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.toxicon.2024.108225","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
A silent killer in the word: Review on Aspergillus flavus strains.
Filamentous fungi are recognized for their significance in food processing and antibiotic production, as well as their capacity to produce mycotoxins. Numerous secondary metabolites have been investigated, and their occurrence in foodstuffs, both in the field and during the storage of agricultural products, poses a substantial health risk to consumers. Several fungal species capable of producing mycotoxins have been documented. However, their presence suggests the potential occurrence of mycotoxins, of which only the most well-known are considered in health risk assessment, thus potentially underestimating the complex mixture to which consumers may be exposed. This review examines the range of secondary metabolites produced by Aspergillus species of the Flavi section found in agricultural products and foodstuffs. Known for their ability to produce aflatoxins, the presence of these fungi typically leads to the investigation of only aflatoxins, and possibly cyclopiazonic acid, in contaminated foods. This review elucidates the secondary metabolites produced by the Flavi section of Aspergillus and examines the associated hazards, to contribute to the assessment of the potential risk that the presence of these fungi in food products may represent.
期刊介绍:
Toxicon has an open access mirror Toxicon: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. An introductory offer Toxicon: X - full waiver of the Open Access fee.
Toxicon''s "aims and scope" are to publish:
-articles containing the results of original research on problems related to toxins derived from animals, plants and microorganisms
-papers on novel findings related to the chemical, pharmacological, toxicological, and immunological properties of natural toxins
-molecular biological studies of toxins and other genes from poisonous and venomous organisms that advance understanding of the role or function of toxins
-clinical observations on poisoning and envenoming where a new therapeutic principle has been proposed or a decidedly superior clinical result has been obtained.
-material on the use of toxins as tools in studying biological processes and material on subjects related to venom and antivenom problems.
-articles on the translational application of toxins, for example as drugs and insecticides
-epidemiological studies on envenoming or poisoning, so long as they highlight a previously unrecognised medical problem or provide insight into the prevention or medical treatment of envenoming or poisoning. Retrospective surveys of hospital records, especially those lacking species identification, will not be considered for publication. Properly designed prospective community-based surveys are strongly encouraged.
-articles describing well-known activities of venoms, such as antibacterial, anticancer, and analgesic activities of arachnid venoms, without any attempt to define the mechanism of action or purify the active component, will not be considered for publication in Toxicon.
-review articles on problems related to toxinology.
To encourage the exchange of ideas, sections of the journal may be devoted to Short Communications, Letters to the Editor and activities of the affiliated societies.