世界上沉默的杀手:黄曲霉菌株研究进展。

IF 2.6 4区 医学 Q2 PHARMACOLOGY & PHARMACY Toxicon Pub Date : 2025-01-06 DOI:10.1016/j.toxicon.2024.108225
Yann Christie Sissinto Adjovi, Joli Prince Mintognissè Fossou, Ulrich Hilarion Ahehehinnou
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引用次数: 0

摘要

丝状真菌因其在食品加工和抗生素生产中的重要作用以及产生真菌毒素的能力而得到认可。已经对许多次生代谢物进行了调查,它们在食品中的出现,无论是在田间还是在农产品储存期间,都对消费者的健康构成重大风险。一些能够产生真菌毒素的真菌物种已被记录在案。然而,它们的存在表明真菌毒素的潜在存在,在健康风险评估中只考虑了最知名的真菌毒素,因此可能低估了消费者可能接触到的复杂混合物。本文综述了在农产品和食品中发现的黄曲霉种产生的次生代谢物的范围。这些真菌以其产生黄曲霉毒素的能力而闻名,它们的存在通常导致在受污染的食物中只调查黄曲霉毒素,可能还有环吡唑酸。这篇综述阐明了曲霉黄素部分产生的次生代谢物,并检查了相关的危害,以有助于评估这些真菌在食品中可能代表的潜在风险。
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A silent killer in the word: Review on Aspergillus flavus strains.

Filamentous fungi are recognized for their significance in food processing and antibiotic production, as well as their capacity to produce mycotoxins. Numerous secondary metabolites have been investigated, and their occurrence in foodstuffs, both in the field and during the storage of agricultural products, poses a substantial health risk to consumers. Several fungal species capable of producing mycotoxins have been documented. However, their presence suggests the potential occurrence of mycotoxins, of which only the most well-known are considered in health risk assessment, thus potentially underestimating the complex mixture to which consumers may be exposed. This review examines the range of secondary metabolites produced by Aspergillus species of the Flavi section found in agricultural products and foodstuffs. Known for their ability to produce aflatoxins, the presence of these fungi typically leads to the investigation of only aflatoxins, and possibly cyclopiazonic acid, in contaminated foods. This review elucidates the secondary metabolites produced by the Flavi section of Aspergillus and examines the associated hazards, to contribute to the assessment of the potential risk that the presence of these fungi in food products may represent.

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来源期刊
Toxicon
Toxicon 医学-毒理学
CiteScore
4.80
自引率
10.70%
发文量
358
审稿时长
68 days
期刊介绍: Toxicon has an open access mirror Toxicon: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. An introductory offer Toxicon: X - full waiver of the Open Access fee. Toxicon''s "aims and scope" are to publish: -articles containing the results of original research on problems related to toxins derived from animals, plants and microorganisms -papers on novel findings related to the chemical, pharmacological, toxicological, and immunological properties of natural toxins -molecular biological studies of toxins and other genes from poisonous and venomous organisms that advance understanding of the role or function of toxins -clinical observations on poisoning and envenoming where a new therapeutic principle has been proposed or a decidedly superior clinical result has been obtained. -material on the use of toxins as tools in studying biological processes and material on subjects related to venom and antivenom problems. -articles on the translational application of toxins, for example as drugs and insecticides -epidemiological studies on envenoming or poisoning, so long as they highlight a previously unrecognised medical problem or provide insight into the prevention or medical treatment of envenoming or poisoning. Retrospective surveys of hospital records, especially those lacking species identification, will not be considered for publication. Properly designed prospective community-based surveys are strongly encouraged. -articles describing well-known activities of venoms, such as antibacterial, anticancer, and analgesic activities of arachnid venoms, without any attempt to define the mechanism of action or purify the active component, will not be considered for publication in Toxicon. -review articles on problems related to toxinology. To encourage the exchange of ideas, sections of the journal may be devoted to Short Communications, Letters to the Editor and activities of the affiliated societies.
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