{"title":"超越肠促胰岛素：靶向神经激肽受体治疗肥胖","authors":"Doreen Thor, Simone Prömel","doi":"10.1038/s41392-024-02100-y","DOIUrl":null,"url":null,"abstract":"<p>In a study published recently in <i>Nature</i>, Sass, Ma, and colleagues describe the neurokinin 2 receptor (NK2R), a G protein-coupled receptor (GPCR), as a novel regulator of food intake as well as energy expenditure, and develop and characterize selective agonists that effectively activate NK2R to promote weight loss. Most interestingly, the authors bridge the gap between rodents and primates, raising hopes for novel treatment options.<sup>1</sup></p>","PeriodicalId":21766,"journal":{"name":"Signal Transduction and Targeted Therapy","volume":"31 1","pages":""},"PeriodicalIF":40.8000,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Beyond incretins: targeting neurokinin receptors for obesity treatment\",\"authors\":\"Doreen Thor, Simone Prömel\",\"doi\":\"10.1038/s41392-024-02100-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>In a study published recently in <i>Nature</i>, Sass, Ma, and colleagues describe the neurokinin 2 receptor (NK2R), a G protein-coupled receptor (GPCR), as a novel regulator of food intake as well as energy expenditure, and develop and characterize selective agonists that effectively activate NK2R to promote weight loss. Most interestingly, the authors bridge the gap between rodents and primates, raising hopes for novel treatment options.<sup>1</sup></p>\",\"PeriodicalId\":21766,\"journal\":{\"name\":\"Signal Transduction and Targeted Therapy\",\"volume\":\"31 1\",\"pages\":\"\"},\"PeriodicalIF\":40.8000,\"publicationDate\":\"2025-01-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Signal Transduction and Targeted Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41392-024-02100-y\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Signal Transduction and Targeted Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41392-024-02100-y","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Beyond incretins: targeting neurokinin receptors for obesity treatment
In a study published recently in Nature, Sass, Ma, and colleagues describe the neurokinin 2 receptor (NK2R), a G protein-coupled receptor (GPCR), as a novel regulator of food intake as well as energy expenditure, and develop and characterize selective agonists that effectively activate NK2R to promote weight loss. Most interestingly, the authors bridge the gap between rodents and primates, raising hopes for novel treatment options.1
期刊介绍：
Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy.
Scope: The journal covers research on major human diseases, including, but not limited to:
Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.
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