Alyssa Howren, Eric C. Sayre, J. Antonio Avina-Zubieta, Joseph H. Puyat, Deborah Da Costa, Hui Xie, Eileen Davidson, Amit Gupta, Mary A. De Vera
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Multivariable logistic regression models were used to evaluate the odds of individuals with IA receiving minimally adequate pharmacotherapy and/or psychological treatment compared to IA-free controls. 6,951 (mean age 54.8 ± 18.3 years; 65.5% female) individuals with IA had incident depression and 3,701 (mean age 52.9 ± 16.8 years; 74.3% female) had incident anxiety. Minimally adequate pharmacotherapy and psychological treatment for depression was respectively observed in 50.5% and 19.6% of those with IA, proportions similar to IA-free controls (pharmacotherapy: aOR 1.10, 95% CI 1.00 to 1.21; psychological: aOR 1.07, 95% CI 0.94 to 1.21). Results were similar regarding anxiety treatment. Individuals with IA had a significantly greater likelihood of dispensing ≥ 1 benzodiazepine (anxiety: IA 45.0%, IA-free controls 39.0%, p-value < 0.001) and ≥ 1 tricyclic antidepressant prescription (anxiety: IA 12.8%, IA-free controls 7.8%, p-value < 0.001). Significantly higher average days’ supply of benzodiazepines was observed for IA (anxiety: IA 123.7 days, controls 112.4 days, p-value = 0.003). A substantial proportion of individuals with IA were not receiving adequate mental health treatment for depression and anxiety, a finding similar for IA-free controls. The undertreatment of mental disorders for people with IA has well-known negative implications for the provision of effective rheumatology care. 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引用次数: 0
摘要
描述药物治疗和心理治疗的模式,并评估炎症性关节炎(IA)患者对偶发抑郁和焦虑的最低限度适当治疗的接受情况。我们使用了来自加拿大不列颠哥伦比亚省的以人群为基础的相关行政卫生数据库来评估IA患者和非IA患者(“无IA对照”)的药物治疗和心理治疗对突发抑郁和/或焦虑的影响。我们将最低限度适当的药物治疗定义为抗抑郁药处方≥84天的供应,适当的心理治疗定义为≥4次咨询/心理治疗服务。使用多变量logistic回归模型来评估IA患者与无IA患者相比接受最低限度药物治疗和/或心理治疗的几率。6951人(平均年龄54.8±18.3岁);65.5%女性)IA患者有抑郁症,3701例(平均年龄52.9±16.8岁;74.3%的女性)有偶发性焦虑。在IA患者中,分别有50.5%和19.6%的患者接受了最低限度的药物治疗和心理治疗,比例与无IA对照组相似(药物治疗:aOR 1.10, 95% CI 1.00 ~ 1.21;心理:aOR 1.07, 95% CI 0.94 ~ 1.21)。焦虑治疗的结果相似。IA患者配用≥1种苯二氮卓类药物(焦虑组:IA 45.0%,无IA对照组39.0%,p值< 0.001)和≥1种三环类抗抑郁药物(焦虑组:IA 12.8%,无IA对照组7.8%,p值< 0.001)的可能性显著增加。IA组苯二氮卓类药物平均供给量显著增加(焦虑组:IA 123.7天,对照组112.4天,p值= 0.003)。相当大比例的IA患者没有接受足够的抑郁症和焦虑症心理健康治疗,这一发现与没有IA的对照组相似。众所周知,IA患者的精神障碍治疗不足对提供有效的风湿病治疗具有负面影响。扩大公共资助的卫生保健,使其包括精神卫生服务,以努力解决未得到满足的咨询需求,这仍然是至关重要的。
Do individuals with inflammatory arthritis receive minimally adequate treatment for incident depression and anxiety: A population-based study
Describe patterns of pharmacotherapy and psychological treatment and evaluate receipt of minimally adequate treatment for incident depression and anxiety in individuals with inflammatory arthritis (IA). We used population-based linked administrative health databases from British Columbia, Canada to evaluate pharmacotherapy and psychological treatments for incident depression and/or anxiety among individuals with IA and without IA (‘IA-free controls’). We defined minimally adequate pharmacotherapy as antidepressant prescriptions filled with ≥ 84 days’ supply and adequate psychological treatment as ≥ 4 counselling/psychotherapy services. Multivariable logistic regression models were used to evaluate the odds of individuals with IA receiving minimally adequate pharmacotherapy and/or psychological treatment compared to IA-free controls. 6,951 (mean age 54.8 ± 18.3 years; 65.5% female) individuals with IA had incident depression and 3,701 (mean age 52.9 ± 16.8 years; 74.3% female) had incident anxiety. Minimally adequate pharmacotherapy and psychological treatment for depression was respectively observed in 50.5% and 19.6% of those with IA, proportions similar to IA-free controls (pharmacotherapy: aOR 1.10, 95% CI 1.00 to 1.21; psychological: aOR 1.07, 95% CI 0.94 to 1.21). Results were similar regarding anxiety treatment. Individuals with IA had a significantly greater likelihood of dispensing ≥ 1 benzodiazepine (anxiety: IA 45.0%, IA-free controls 39.0%, p-value < 0.001) and ≥ 1 tricyclic antidepressant prescription (anxiety: IA 12.8%, IA-free controls 7.8%, p-value < 0.001). Significantly higher average days’ supply of benzodiazepines was observed for IA (anxiety: IA 123.7 days, controls 112.4 days, p-value = 0.003). A substantial proportion of individuals with IA were not receiving adequate mental health treatment for depression and anxiety, a finding similar for IA-free controls. The undertreatment of mental disorders for people with IA has well-known negative implications for the provision of effective rheumatology care. It remains fundamental to expand publicly funded health care to include mental health services in an effort to address unmet counselling needs.
期刊介绍:
Established in 1999, Arthritis Research and Therapy is an international, open access, peer-reviewed journal, publishing original articles in the area of musculoskeletal research and therapy as well as, reviews, commentaries and reports. A major focus of the journal is on the immunologic processes leading to inflammation, damage and repair as they relate to autoimmune rheumatic and musculoskeletal conditions, and which inform the translation of this knowledge into advances in clinical care. Original basic, translational and clinical research is considered for publication along with results of early and late phase therapeutic trials, especially as they pertain to the underpinning science that informs clinical observations in interventional studies.