过氧化氢酶组装纳米颗粒用于急性酒精性胃炎的PA/CT双模成像和修复。

IF 5.5 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-01-09 DOI:10.1016/j.bioadv.2025.214181

Hongchang Yu , Can Chen , Wei Feng , Yuan Gu , Xijie Jiang , Jibin Zhang , Yanli Lu , Jiangtao Zhu , Zhen Jiang , Yong Wang

{"title":"过氧化氢酶组装纳米颗粒用于急性酒精性胃炎的PA/CT双模成像和修复。","authors":"Hongchang Yu , Can Chen , Wei Feng , Yuan Gu , Xijie Jiang , Jibin Zhang , Yanli Lu , Jiangtao Zhu , Zhen Jiang , Yong Wang","doi":"10.1016/j.bioadv.2025.214181","DOIUrl":null,"url":null,"abstract":"<div><div>The development of simple, rapid, sensitive and noninvasive theranostic agents for acute gastritis is crucial. Herein, an engineering catalase-conjugated bismuth nanoparticle was fabricated for near-infrared photoacoustic imaging and computed tomography imaging of acute alcoholic gastritis. This nanoparticle could quickly respond to H<sub>2</sub>O<sub>2</sub> and H<sup>+</sup> overexpressed in the microenvironment of acute gastritis in mice, emitting strong signals for precise localization. Additionally, it adhered to the damaged gastric mucosa for an extended period, acting as a long-acting mucosal protector by inhibiting related inflammatory reactions and promoting mucosal repair. The use of this catalase-assembled nanoparticle could extend its residence time in the stomach, thereby reducing the drug dose and treatment duration. These findings of our study underscored the potential of this multifunctional nanoplatform for integrated diagnosis and treatment of gastrointestinal inflammatory diseases.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"169 ","pages":"Article 214181"},"PeriodicalIF":5.5000,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Catalase-assembled nanoparticles for PA/CT dual-modality imaging and repair of acute alcoholic gastritis\",\"authors\":\"Hongchang Yu , Can Chen , Wei Feng , Yuan Gu , Xijie Jiang , Jibin Zhang , Yanli Lu , Jiangtao Zhu , Zhen Jiang , Yong Wang\",\"doi\":\"10.1016/j.bioadv.2025.214181\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The development of simple, rapid, sensitive and noninvasive theranostic agents for acute gastritis is crucial. Herein, an engineering catalase-conjugated bismuth nanoparticle was fabricated for near-infrared photoacoustic imaging and computed tomography imaging of acute alcoholic gastritis. This nanoparticle could quickly respond to H<sub>2</sub>O<sub>2</sub> and H<sup>+</sup> overexpressed in the microenvironment of acute gastritis in mice, emitting strong signals for precise localization. Additionally, it adhered to the damaged gastric mucosa for an extended period, acting as a long-acting mucosal protector by inhibiting related inflammatory reactions and promoting mucosal repair. The use of this catalase-assembled nanoparticle could extend its residence time in the stomach, thereby reducing the drug dose and treatment duration. These findings of our study underscored the potential of this multifunctional nanoplatform for integrated diagnosis and treatment of gastrointestinal inflammatory diseases.</div></div>\",\"PeriodicalId\":51111,\"journal\":{\"name\":\"Materials Science & Engineering C-Materials for Biological Applications\",\"volume\":\"169 \",\"pages\":\"Article 214181\"},\"PeriodicalIF\":5.5000,\"publicationDate\":\"2025-01-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Materials Science & Engineering C-Materials for Biological Applications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2772950825000081\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Science & Engineering C-Materials for Biological Applications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772950825000081","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}

引用次数: 0

摘要

开发简单、快速、灵敏、无创的急性胃炎治疗药物至关重要。本文制备了一种工程过氧化氢酶共轭铋纳米颗粒，用于急性酒精性胃炎的近红外光声成像和计算机断层成像。该纳米颗粒能够快速响应小鼠急性胃炎微环境中过表达的H2O2和H+，发出强信号进行精确定位。此外，它能长时间粘附在受损的胃粘膜上，通过抑制相关炎症反应，促进粘膜修复，起到长效粘膜保护剂的作用。使用这种过氧化氢酶组装的纳米颗粒可以延长其在胃中的停留时间，从而减少药物剂量和治疗时间。我们的研究结果强调了这种多功能纳米平台在综合诊断和治疗胃肠道炎症性疾病方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Catalase-assembled nanoparticles for PA/CT dual-modality imaging and repair of acute alcoholic gastritis

The development of simple, rapid, sensitive and noninvasive theranostic agents for acute gastritis is crucial. Herein, an engineering catalase-conjugated bismuth nanoparticle was fabricated for near-infrared photoacoustic imaging and computed tomography imaging of acute alcoholic gastritis. This nanoparticle could quickly respond to H₂O₂ and H⁺ overexpressed in the microenvironment of acute gastritis in mice, emitting strong signals for precise localization. Additionally, it adhered to the damaged gastric mucosa for an extended period, acting as a long-acting mucosal protector by inhibiting related inflammatory reactions and promoting mucosal repair. The use of this catalase-assembled nanoparticle could extend its residence time in the stomach, thereby reducing the drug dose and treatment duration. These findings of our study underscored the potential of this multifunctional nanoplatform for integrated diagnosis and treatment of gastrointestinal inflammatory diseases.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Materials Science & Engineering C-Materials for Biological Applications 工程技术-材料科学：生物材料

CiteScore

17.80

自引率

0.00%

发文量

501

审稿时长

27 days

期刊介绍： Biomaterials Advances, previously known as Materials Science and Engineering: C-Materials for Biological Applications (P-ISSN: 0928-4931, E-ISSN: 1873-0191). Includes topics at the interface of the biomedical sciences and materials engineering. These topics include: • Bioinspired and biomimetic materials for medical applications • Materials of biological origin for medical applications • Materials for "active" medical applications • Self-assembling and self-healing materials for medical applications • "Smart" (i.e., stimulus-response) materials for medical applications • Ceramic, metallic, polymeric, and composite materials for medical applications • Materials for in vivo sensing • Materials for in vivo imaging • Materials for delivery of pharmacologic agents and vaccines • Novel approaches for characterizing and modeling materials for medical applications Manuscripts on biological topics without a materials science component, or manuscripts on materials science without biological applications, will not be considered for publication in Materials Science and Engineering C. New submissions are first assessed for language, scope and originality (plagiarism check) and can be desk rejected before review if they need English language improvements, are out of scope or present excessive duplication with published sources. Biomaterials Advances sits within Elsevier''s biomaterials science portfolio alongside Biomaterials, Materials Today Bio and Biomaterials and Biosystems. As part of the broader Materials Today family, Biomaterials Advances offers authors rigorous peer review, rapid decisions, and high visibility. We look forward to receiving your submissions!