阿莫西林、头孢氨苄和四环素-盐酸对大鼠体内肠道l -亮氨酸运输的影响。

Drug-nutrient interactions Pub Date : 1988-01-01

Y Barcina, A Ilundain, J Larralde

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摘要

采用体内法研究了阿莫西林、头孢氨苄和四环素-盐酸对大鼠肠道l -亮氨酸吸收的影响。结果表明，阿莫西林对l -亮氨酸转运具有时间依赖性和可逆性的抑制作用，而其他两种抗生素对l -亮氨酸转运的抑制作用不可逆。光镜研究显示，三种抗生素对肠道黏膜形态无影响。

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Effect of amoxicillin, cephalexin, and tetracycline-HCl on intestinal L-leucine transport in the rat in vivo.

By utilising an in vivo technique the effects of amoxicillin, cephalexin, and tetracycline-HCl on intestinal L-leucine absorption were studied in the rat. The results showed that amoxicillin caused a time-dependent and reversible inhibition of L-leucine transport while the inhibition induced by the other two antibiotics tested was not reversible. Light microscopic studies revealed that the three antibiotics were without effect on intestinal mucosal morphology.

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Drug-nutrient interactions

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