Theophylline toxicity in a preterm infant: selected clinical aspects.

A case of parent-induced theophylline toxicity in a preterm infant is described. Despite a theophylline level of 97 mcg/ml no clinical seizure activity was apparent. Pharmacokinetic data suggested that use of oral activated charcoal may have enhanced drug clearance. Further study is necessary before such therapy can be routinely advocated. Additional clinical features are discussed, including avoidance of dosing errors through careful instruction of all caretakers prior to discharge.