[母亲潜伏性人型疱疹病毒感染与新生儿被动获得性免疫]。

M Bujko-Klisura, V Sulović, L Marković, R Dotlić
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引用次数: 0

摘要

本研究旨在确定健康孕妇潜伏性人疱疹病毒1型感染的频率。这种感染只能通过血液中抗人疱疹病毒1型抗体的存在来检测。本文采用补体固定试验对102例产妇和脐带血样进行了分析。母亲的平均几何抗体滴度为13.968。超过90%的被检查的孕妇血液中有抗HVH 1型抗体。102对(母-脐带)血样中,34对(33.34%)产妇血和脐带血中抗HVH 1型抗体滴度相同,62对(60.78%)产妇血中抗HVH 1型抗体滴度比产妇高2倍。这种抗HVH 1型抗体的经胎盘转移似乎在保护新生儿免受全身性HVH感染方面起着重要作用,尽管这种保护的持续时间有限,而且不如细胞诱导免疫那么有效。
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[Latent herpesvirus hominis type 1 infection in the mother and passive acquired immunity in the newborn infant].

The study aimed at determining the frequency of latent herpes virus hominis type 1 infection in healthy parturients. The infection can be detected only by the presence of anti herpes virus hominis type 1 antibodies in their blood. To this end 102 blood samples of both parturients and the umbilical cord were concurrently analysed by the complement fixation test. The mean geometrical antibody titer value in mothers was 13.968. More than 90% of the parturients examined had anti HVH type 1 antibodies in their blood. Out of 102 pairs (mother--umbilical cord) of blood samples, in 34 (33.34%) the observed anti HVH type 1 antibody titer was the same in the parturients' blood and in the umbilical cord blood, while in 62 samples (60.78%) the titer of these antibodies was twice as high in the umbilical cord blood than in the parturients. It appears that this transplacental transfer of anti HVH type 1 antibodies plays a significant role in the protection of the newborn against generalized HVH infection, although this kind of protection is limited in its duration and not so efficacious as cell-induced immunity.

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