{"title":"反复大剂量纳洛酮治疗精神分裂症无疗效。","authors":"D Naber, K Leibl","doi":"10.1055/s-2007-1017446","DOIUrl":null,"url":null,"abstract":"<p><p>6 schizophrenic patients were treated in a cross-over design for 4 days each with 20 mg naloxone or placebo. No patient showed a significant change of his or her psychotic behaviour. This result is not in agreement with an antipsychotic action of the opiate antagonist.</p>","PeriodicalId":19840,"journal":{"name":"Pharmacopsychiatria","volume":"16 2","pages":"43-5"},"PeriodicalIF":0.0000,"publicationDate":"1983-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2007-1017446","citationCount":"10","resultStr":"{\"title\":\"Repeated high dosage naloxone treatment without therapeutic efficacy in schizophrenic patients.\",\"authors\":\"D Naber, K Leibl\",\"doi\":\"10.1055/s-2007-1017446\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>6 schizophrenic patients were treated in a cross-over design for 4 days each with 20 mg naloxone or placebo. No patient showed a significant change of his or her psychotic behaviour. This result is not in agreement with an antipsychotic action of the opiate antagonist.</p>\",\"PeriodicalId\":19840,\"journal\":{\"name\":\"Pharmacopsychiatria\",\"volume\":\"16 2\",\"pages\":\"43-5\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1983-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1055/s-2007-1017446\",\"citationCount\":\"10\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacopsychiatria\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1055/s-2007-1017446\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacopsychiatria","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/s-2007-1017446","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Repeated high dosage naloxone treatment without therapeutic efficacy in schizophrenic patients.
6 schizophrenic patients were treated in a cross-over design for 4 days each with 20 mg naloxone or placebo. No patient showed a significant change of his or her psychotic behaviour. This result is not in agreement with an antipsychotic action of the opiate antagonist.
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