K Yamamoto, K Makimura, T Sudo, K Shibuya, K Uchida, H Yamaguchi
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引用次数: 15
摘要
用环磷酰胺处理的小鼠，静脉注射滴定剂量的日本毛磷虫TIMM3140或TIMM3144。肺、心、肝、脾、肾和脑的死亡率和生存时间与接种量大小和真菌生长有关。氟康唑和两性霉素B可延长生存时间，降低肾脏CFU，且氟康唑优于两性霉素B。抗真菌治疗可降低血清(1- >3)- β - d -葡聚糖水平，且与肾脏CFU/器官相关，但与血液CFU/ml无关。
Experimental disseminated trichosporonosis in mice: tissue distribution and therapy with antifungal agents.
Mice treated with cyclophosphamide were infected intravenously with titrated doses of Trichosporon asahii TIMM3140 or TIMM3144. Mortality and survival time correlated with inoculum size and fungal growth was found in the lung, heart, liver, spleen, kidney and brain. Fluconazole and amphotericin B prolonged survival time and reduced the CFU in the kidney, with fluconazole being superior to amphotericin B. The serum level of (1-->3)-beta-D-glucan was reduced by antifungal therapy and correlated well with the CFU/organ in kidney, but not CFU/ml in blood.
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