猪因误食七香籽而出现局灶性对称脑软化症。

Veterinary and human toxicology Pub Date : 2004-12-01
Fabiano N Oliveira, Ricardo R Barros, Daniel R Rissi, Raquel R Rech, Rafael A Fighera, Claudio S L Barros
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引用次数: 0

摘要

据报道,猪因误食七香种子引起的自发性神经系统疾病暴发,并在同一种猪中繁殖。自然暴发时发病率为25% ~ 40%,死亡率为8.5% ~ 20%,致死率为25% ~ 66%。临床表现为不同程度的步态不协调、跌倒、胸骨平卧、后肢基底位宽、侧卧和死亡。5头(a - e)猪分别饲喂含有10%(猪a)、15%(猪B)和20%(猪C-E)籼稻种子的日粮,进行中毒实验繁殖。实验开始后16、21、24小时,A、B猪被安乐死,C-E猪死于急性疾病。临床症状与自发暴发的猪相似。饲粮中添加20%籼米籽(C-E)后,猪脑组织病理表现为充血、水肿、出血,细胞核和脑端皮层毛细血管内皮肿胀。饲喂10%和15%印度麻黄菌的猪在马来acia的离散局灶对称区出现组织病理学改变。这些发现表明,一种或多种有毒原理的印度种子负责神经系统疾病,临床结果和病理改变是剂量依赖性的。猪因摄入籼米种子而形成对称的黑体灶,影响前庭核、小脑核、壳核以及中脑黑质、动眼肌核和红核;因此,局灶性对称脑软化症被认为是一个更好的名称。
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Focal symmetrical encephalomalacia in swine from ingestion of Aeschynomene indica seeds.

A spontaneous outbreak of neurological disease in swine caused by the ingestion of Aeschynomene indica seeds and reproduction of the disease in the same specie are reported. In the natural outbreak the morbidity, mortality and lethality rates were respectively 25%-40%, 8.5%-20%, and 25%-66%. Clinical signs were variable degrees of incoordination of gait, falls, sternal recumbency with wide base stance of the hind limbs, lateral recumbency and death. For experimental reproduction of the intoxication, 5 (A-E) pigs were fed a ration containing 10% (PigA), 15% (Pig B) and 20% (Pigs C-E) of A. indica seeds. Pigs A and B were euthanatized and Pigs C-E died of acute disease respectively 16, 21 and 24 hours after the start of the experiment. Clinical signs were similar to those observed in pigs from the spontaneous outbreak. Histopathological findings in the brain of pigs fed rations with 20% A. indica seeds (C-E) were congestion, edema and hemorrhage and swollen capillary endothelia in nuclei and in the telencephalic cortex. Pigs fed 10% and 15% A. indica had histopathological changes in the brain of discrete focal symmetrical areas of malacia. These findings indicate that one or more toxic principles in A. indica seeds are responsible for this neurological condition and that clinical outcome and pathological changes are dose-dependent. The symmetrical malacic foci from the ingestion of A. indica seeds in pigs affected vestibular and cerebellar nuclei, putamen, and the mesencephalic substantia nigra, oculomotor, and red nucleus; thus, focal symmetrical encephalomalacia is suggested as a better name for the disease.

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