脂肪移植和富血小板血浆在伤口愈合中的应用:动物研究的组织学综述。

IF 3.5 4区 生物学 Q2 ENDOCRINOLOGY & METABOLISM Adipocyte Pub Date : 2021-12-01 DOI:10.1080/21623945.2021.1876374
Grant S Nolan, Oliver J Smith, Gavin Jell, Afshin Mosahebi
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引用次数: 15

摘要

干细胞可能成为一种新型的自体治疗慢性伤口的基础,比如糖尿病足溃疡。脂肪移植物含有脂肪源性干细胞(ADSC),但移植物内细胞存活率低是一个主要限制。富血小板血浆(PRP)可能增加移植物存活。本文综述了脂肪移植、ADSC和PRP在伤口愈合中的动物组织学研究。对主要电子数据库进行了文献回顾,并进行了叙述综合。数据来自30项动物研究。ADSC增加血管生成超过14天,通常在临床上加速伤口愈合。ADSC对伤口愈合受损的动物(如糖尿病)有更大的作用。活化的PRP增加了脂肪移植物的生存能力。尽管有大量的研究,但质量是可变的,这削弱了证据。它确实表明ADSC有好处,特别是在受损的伤口愈合方面。需要高质量的人体证据来确定其临床有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Fat grafting and platelet-rich plasma in wound healing: a review of histology from animal studies.

Stem cells could form the basis of a novel, autologous treatment for chronic wounds like diabetic foot ulcers. Fat grafts contain adipose-derived stem cells (ADSC) but low survival of cells within the grafts is a major limitation. Platelet-rich plasma (PRP) may increase graft survival. This review examines the histology from animal studies on fat grafting, ADSC and PRP in wound healing. A literature review of major electronic databases was undertaken, and narrative synthesis performed. Data from 30 animal studies were included. ADSC increase angiogenesis over 14 days and often clinically accelerated wound healing. ADSC had a greater effect in animals with impaired wound healing (e.g. diabetes). Activated PRP increased viability of fat grafts. Despite the high number of studies, the quality is variable which weakens the evidence. It does suggest there is a benefit of ADSC, particularly in impaired wound healing. High-quality evidence in humans is required, to establish its clinical usefulness.

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来源期刊
Adipocyte
Adipocyte Medicine-Histology
CiteScore
6.50
自引率
3.00%
发文量
46
审稿时长
32 weeks
期刊介绍: Adipocyte recognizes that the adipose tissue is the largest endocrine organ in the body, and explores the link between dysfunctional adipose tissue and the growing number of chronic diseases including diabetes, hypertension, cardiovascular disease and cancer. Historically, the primary function of the adipose tissue was limited to energy storage and thermoregulation. However, a plethora of research over the past 3 decades has recognized the dynamic role of the adipose tissue and its contribution to a variety of physiological processes including reproduction, angiogenesis, apoptosis, inflammation, blood pressure, coagulation, fibrinolysis, immunity and general metabolic homeostasis. The field of Adipose Tissue research has grown tremendously, and Adipocyte is the first international peer-reviewed journal of its kind providing a multi-disciplinary forum for research focusing exclusively on all aspects of adipose tissue physiology and pathophysiology. Adipocyte accepts high-profile submissions in basic, translational and clinical research.
期刊最新文献
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