rs174537 FADS1多态性与腹部和股皮下脂肪组织免疫细胞谱之间的关系:一项针对肥胖成人的探索性研究

IF 3.5 4区 生物学 Q2 ENDOCRINOLOGY & METABOLISM Adipocyte Pub Date : 2021-12-01 DOI:10.1080/21623945.2021.1888470
Chenxuan Wang, Jessica Murphy, Kerri Z Delaney, Natalie Khor, José A Morais, Michael A Tsoukas, Dana E Lowry, David M Mutch, Sylvia Santosa
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引用次数: 1

摘要

脂肪酸去饱和酶1 (FADS1)多态性改变皮下脂肪组织(SAT)脂肪酸含量;然而,关于FADS1变异与SAT炎症状态之间的关联,现有证据有限且相互矛盾。为了推进这一领域,我们开展了一项探索性研究,探讨肥胖个体中FADS1中常见的rs174537多态性是否与腹部和股骨SAT的免疫细胞谱相关。采用qPCR和流式细胞术分别检测SAT库中FADS1基因表达和免疫细胞谱。尽管FADS1基因的表达与基因型相关,但在两个试验点均未观察到与免疫细胞谱的关联。我们的研究提供了额外的证据,证明FADS1中的rs174537对肥胖SAT的炎症状态影响最小。
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Association between rs174537 FADS1 polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity.

Fatty acid desaturase 1 (FADS1) polymorphisms alter fatty acid content in subcutaneous adipose tissue (SAT); however, existing evidence is limited and conflicting regarding the association between FADS1 variants and SAT inflammatory status. To advance this area, we conducted an exploratory study to investigate whether the common rs174537 polymorphism in FADS1 was associated with immune cell profiles in abdominal and femoral SAT in individuals with obesity. FADS1 gene expression and immune cell profiles in SAT depots were assessed by qPCR and flow cytometry, respectively. Although FADS1 gene expression was associated with genotype, no associations were observed with immune cell profiles in either depot. Our study provides additional evidence that rs174537 in FADS1 has minimal impact on inflammatory status in obese SAT.

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来源期刊
Adipocyte
Adipocyte Medicine-Histology
CiteScore
6.50
自引率
3.00%
发文量
46
审稿时长
32 weeks
期刊介绍: Adipocyte recognizes that the adipose tissue is the largest endocrine organ in the body, and explores the link between dysfunctional adipose tissue and the growing number of chronic diseases including diabetes, hypertension, cardiovascular disease and cancer. Historically, the primary function of the adipose tissue was limited to energy storage and thermoregulation. However, a plethora of research over the past 3 decades has recognized the dynamic role of the adipose tissue and its contribution to a variety of physiological processes including reproduction, angiogenesis, apoptosis, inflammation, blood pressure, coagulation, fibrinolysis, immunity and general metabolic homeostasis. The field of Adipose Tissue research has grown tremendously, and Adipocyte is the first international peer-reviewed journal of its kind providing a multi-disciplinary forum for research focusing exclusively on all aspects of adipose tissue physiology and pathophysiology. Adipocyte accepts high-profile submissions in basic, translational and clinical research.
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