尿中性粒细胞glatinase-associated lipocalin水平(uNGAL)可以预测婴儿先天性肾积水的严重程度。

IF 1.4 Q4 IMMUNOLOGY American journal of clinical and experimental immunology Pub Date : 2021-02-15 eCollection Date: 2021-01-01
Rahimpour Amiri, Hiwa Hosseini, Zahra Sanaei, Saba Shamahmoudi, Ghasem Solgi
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引用次数: 0

摘要

临床研究结果表明,尿中性粒细胞明胶酶相关脂钙蛋白(uNGAL)水平可能是一个高度敏感的生物标志物和进行性肾小管和肾小球损伤的预测指标。本横断面研究旨在确定uNGAL对先天性肾积水婴儿的预测能力。对45例2岁以下先天性梗阻性尿病患儿(男30例,女15例)进行尿肌酐、uNGAL及uNGAL/ ucreatiine (Cr)比值测定。62.2%为轻度,15.6%为中度,22.2%为重度肾积水。我们观察到重症患者的uNGAL水平明显高于轻中度患者(P=0.002)。重度肾积水患儿uNGAL/uCr比值高于轻中度患儿(P=0.006)。相关分析显示,uCr水平与盆腔直径呈显著负相关(P=0.002), uNGAL及uNGAL/uCr比值与盆腔直径呈正相关(P=0.002)
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Urinary neutrophil glatinase-associated lipocalin level (uNGAL) may predict the severity of congenital hydronephrosis in infants.

Clinical findings suggest that the urinary neutrophil gelatinase-associated lipocalin (uNGAL) level may be a highly sensitive biomarker and predictor of progressive tubular and glomerular injury. This cross-sectional study aimed to determine the predictive power of uNGAL in infants with congenital hydronephrosis. Forty-five children (30 males and 15 females) under the age of two with congenital obstructive uropathy were evaluated for urinary levels of creatinine, uNGAL and uNGAL/uCreatinine (Cr) ratio. Totally, 62.2% of patients had mild, 15.6% had moderate and 22.2% had severe hydronephrosis. We observed a higher significantly uNGAL level in cases with severe form than cases with mild to moderate forms (P=0.002). Also, infants with severe hydronephrosis showed a higher ratio of uNGAL/uCr compared with mild to moderate cases (P=0.006). Correlation analysis showed a significant inverse correlation between uCr levels and pelvic diameter (P=0.002) and direct correlations between uNGAL and uNGAL/uCr ratio and pelvic diameter (P<0.001). By defining a cut-off point of 73.7 ng/ml for uNGAL in ROC analysis, we observed a sensitivity of 70.0% and a specificity of 91.4% forthe prediction of severe hydronephrosis. Our results indicate the potential predictive valueof uNGAL and uNGAL/uCr ratio for hydronephrosis and, more importantly, for discrimination of the severe hydronephrosis from mild to moderate forms.

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