[脊髓骨髓瘤手术治疗的适应症和根治性]。

Svatopluk Rehák, Vladimír Maisnar, Václav Málek, Jirí Náhlovský, Pavel Ryska, Kurt Kaltofen, Tomás Cesák, Martin Kanta, Jaroslav Adamkov, Tomás Hosszú, Eva Cermáková
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摘要

在我们的19例脊髓骨髓瘤手术患者中,17例(89%)患者首次表现为恶性血液病。入院手术指征有18例(92%)患者表现为脊柱压迫或原因不明的椎体溶骨性疼痛,其中17例(63%)患者表现为神经功能障碍。在图形检查的基础上,最常见的怀疑是脊柱在原发灶未知的转移性痛苦,大多数病例的基本诊断是在手术后确定的。在决定手术干预的选择时,通常缺少关于脊柱肿瘤类型的重要数据,特别是无法估计患者的预期寿命。在决定手术的激进性时,我们从脊柱受压程度和脊柱病理过程的外科特征出发。手术的目的是对肿瘤中的脊髓进行减压,稳定脊柱的受损部分。我们决定对7例(37%)患者行肿瘤根治后稳定脊柱重建,全部临床好转,本组仅有2例(29%)患者死亡。在接下来的12例患者中,我们只对脊柱进行了姑息性手术,即63%,只有6例患者神经功能得到改善,即50%,10例患者死亡,即83%。
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[Indication and radicality of surgical treatment in spinal myeloma].

In our set of 19 operated patients with spinal myeloma it was in 17 patients (89%) the first manifestation of malignant haematological disease. Indication for admission for surgery were in 18 patients (92%) graphical signs of spinal compression of osteolytic affliction of the vertebra of unclear aetiology, which in 17 (63%) of patients were demonstrated by neurological deficit. On the basis of graphical examinations the most frequent suspicion was on metastatic affliction of the spine at unknown primary focus and the basic diagnosis was determined after the operation at most of cases. In decision about the choice of radicalness of surgery intervention important data about the type of tumour in the spine were usually missing and it especially did not make possible to estimate the life expectation of the patient. When deciding about the radicalness of the surgery, we started from the degree of spinal compression and surgical character of pathological process in the spine. The aim of the operation is to decompress the spinal cord in tumour and to stabilize the afflicted part of the spine. Radical extirpation of tumour followed with stabilization and spine reconstruction we decided to carry out in 7 patients, i.e. 37%, all of them clinically improved and from this group only 2 patients (29%) died till now. We carried out only palliative surgery on the spine in next 12 patients, i.e. in 63%, only 6 patients improved neurologically, i.e. 50% and 10 patients, i.e. 83% died till now.

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