“我没疯!”阿尔茨海默病中失认症的研究]。

E Salmon
{"title":"“我没疯!”阿尔茨海默病中失认症的研究]。","authors":"E Salmon","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Anosognosia corresponds to a lack of awareness about the own clinical disease of a patient. Anosognosia is frequent in Alzheimer's disease (AD). Researchers explore several hypotheses, psychological (deny) or cognitive (an association of memory and executive impairment), and recently models describing the dynamics of self representation provided convincing interpretations. Self models are modular. They comprise a central executive organising information processing according to subject's objectives. The central executive takes into account personal beliefs and social schemata and it uses autobiographical memory. The analysis of information by the self system leads to decision taking that relies on two principles, self continuity and adaptation. Neuroimaging studies showed that self reflection activates specific brain regions, comprising the ventromedial prefrontal cortex, the medial parietal and posterior cingulate cortex and the inferior parietal lobule. Other studies demonstrated that the same regions are particularly affected by AD. Experimental data currently allows making relationships between regional brain involvement, diverse difficulties in self representation and different forms of anosognosia for clinical status in AD patients.</p>","PeriodicalId":75641,"journal":{"name":"Bulletin et memoires de l'Academie royale de medecine de Belgique","volume":"165 7-9","pages":"339-48; discussion 349-50"},"PeriodicalIF":0.0000,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[\\\"I'm not crazy!\\\" Studies of agnosia in Alzheimer's disease].\",\"authors\":\"E Salmon\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Anosognosia corresponds to a lack of awareness about the own clinical disease of a patient. Anosognosia is frequent in Alzheimer's disease (AD). Researchers explore several hypotheses, psychological (deny) or cognitive (an association of memory and executive impairment), and recently models describing the dynamics of self representation provided convincing interpretations. Self models are modular. They comprise a central executive organising information processing according to subject's objectives. The central executive takes into account personal beliefs and social schemata and it uses autobiographical memory. The analysis of information by the self system leads to decision taking that relies on two principles, self continuity and adaptation. Neuroimaging studies showed that self reflection activates specific brain regions, comprising the ventromedial prefrontal cortex, the medial parietal and posterior cingulate cortex and the inferior parietal lobule. Other studies demonstrated that the same regions are particularly affected by AD. Experimental data currently allows making relationships between regional brain involvement, diverse difficulties in self representation and different forms of anosognosia for clinical status in AD patients.</p>\",\"PeriodicalId\":75641,\"journal\":{\"name\":\"Bulletin et memoires de l'Academie royale de medecine de Belgique\",\"volume\":\"165 7-9\",\"pages\":\"339-48; discussion 349-50\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bulletin et memoires de l'Academie royale de medecine de Belgique\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin et memoires de l'Academie royale de medecine de Belgique","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

病感失认症对应于对患者自身临床疾病缺乏认识。病感失认症在阿尔茨海默病(AD)中很常见。研究人员探索了几种假设,心理上的(否认)或认知上的(记忆和执行障碍的关联),最近描述自我表征动态的模型提供了令人信服的解释。自我模型是模块化的。它们包括一个根据主体目标组织信息处理的中央执行机构。中央执行系统考虑个人信仰和社会图式,并使用自传式记忆。自我系统对信息的分析导致决策依赖于两个原则,即自我连续性和适应性。神经影像学研究表明,自我反思激活了特定的大脑区域,包括腹内侧前额叶皮层、内侧顶叶和后扣带皮层以及顶叶下小叶。其他研究表明,同样的区域特别容易受到阿尔茨海默病的影响。目前的实验数据允许在AD患者的临床状态中建立脑区域受累、各种自我表征困难和不同形式的病感失认之间的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
["I'm not crazy!" Studies of agnosia in Alzheimer's disease].

Anosognosia corresponds to a lack of awareness about the own clinical disease of a patient. Anosognosia is frequent in Alzheimer's disease (AD). Researchers explore several hypotheses, psychological (deny) or cognitive (an association of memory and executive impairment), and recently models describing the dynamics of self representation provided convincing interpretations. Self models are modular. They comprise a central executive organising information processing according to subject's objectives. The central executive takes into account personal beliefs and social schemata and it uses autobiographical memory. The analysis of information by the self system leads to decision taking that relies on two principles, self continuity and adaptation. Neuroimaging studies showed that self reflection activates specific brain regions, comprising the ventromedial prefrontal cortex, the medial parietal and posterior cingulate cortex and the inferior parietal lobule. Other studies demonstrated that the same regions are particularly affected by AD. Experimental data currently allows making relationships between regional brain involvement, diverse difficulties in self representation and different forms of anosognosia for clinical status in AD patients.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
[Belgium Royal Academy of Medicine membership list]. [Music, composers and psychopathology: the psychiatrist's view]. [Contributions of immunogenic cell death to the efficacy of anticancer chemotherapy]. [Cancer stem cells]. [Surgical treatment of female stress urinary incontinence: where are we in 2011?].
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1