[2011年前列腺癌筛查与治疗利用情况]。

B Tombal
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引用次数: 0

摘要

前列腺癌是50岁以上男性中最常见的癌症。然而,由于大多数前列腺癌是生长缓慢的非致死性肿瘤,因此死亡率很低。PSA筛查的引入对前列腺癌的流行病学产生了深远的影响。患有侵袭性疾病的男性可以更快地得到诊断,以便更有效地进行根治性治疗。但PSA筛查也揭示了许多惰性癌症,如果不被发现,这些癌症不会威胁到患者。对惰性癌症的系统治疗可能会导致许多男性遭受不必要的副作用。由于这个原因,PSA筛查的真正好处仍然是一个激烈争论的问题。然而,基于信息、对侵袭性疾病的正确识别和早期整合新的生物标志物,前列腺癌筛查的伦理方法仍有空间。
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[Utilization of screening and treatment of prostate cancer in 2011].

Prostate cancer is the most prevalent cancer in men aged fifty or more. Resulting mortality, however, is low since most prostatic cancers are slow-growing, non-lethal tumours. The introduction of PSA screening has profoundly impacted on the epidemiology of prostate cancer. Men bearing aggressive disease are diagnosed sooner so that radical treatment can be applied more effectively. But PSA screening also unveil many indolent cancers that would have not threaten the patient if left undiscovered. Systematic treatment of indolent cancers may result into many men being exposed to unwanted side effects. For this reason, the true benefit of PSA screening is still a matter of intense debate. Nevertheless, there is room for an ethical approach of prostate cancer screening, based on information, correct identification of aggressive disease and early integration of new biomarkers.

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