30 岁突触修饰的 BCM 理论:理论与实验的互动

IF 28.7 1区 医学 Q1 NEUROSCIENCES Nature Reviews Neuroscience Pub Date : 2012-10-19 DOI:10.1038/nrn3353
Leon N Cooper, Mark F. Bear
{"title":"30 岁突触修饰的 BCM 理论:理论与实验的互动","authors":"Leon N Cooper, Mark F. Bear","doi":"10.1038/nrn3353","DOIUrl":null,"url":null,"abstract":"The BCM theory of synaptic plasticity is now 30 years old. In this Perspective article, Cooper and Bear discuss how this theory has advanced our understanding of synaptic plasticity, learning and memory and highlight the important role that theory can have in neuroscience research. Thirty years have passed since the publication of Elie Bienenstock, Leon Cooper and Paul Munro''s ''Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex'', known as the BCM theory of synaptic plasticity. This theory has guided experimentalists to discover some fundamental properties of synaptic plasticity and has provided a mathematical structure that bridges molecular mechanisms and systems-level consequences of learning and memory storage.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"13 11","pages":"798-810"},"PeriodicalIF":28.7000,"publicationDate":"2012-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/nrn3353","citationCount":"309","resultStr":"{\"title\":\"The BCM theory of synapse modification at 30: interaction of theory with experiment\",\"authors\":\"Leon N Cooper, Mark F. Bear\",\"doi\":\"10.1038/nrn3353\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The BCM theory of synaptic plasticity is now 30 years old. In this Perspective article, Cooper and Bear discuss how this theory has advanced our understanding of synaptic plasticity, learning and memory and highlight the important role that theory can have in neuroscience research. Thirty years have passed since the publication of Elie Bienenstock, Leon Cooper and Paul Munro''s ''Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex'', known as the BCM theory of synaptic plasticity. This theory has guided experimentalists to discover some fundamental properties of synaptic plasticity and has provided a mathematical structure that bridges molecular mechanisms and systems-level consequences of learning and memory storage.\",\"PeriodicalId\":49142,\"journal\":{\"name\":\"Nature Reviews Neuroscience\",\"volume\":\"13 11\",\"pages\":\"798-810\"},\"PeriodicalIF\":28.7000,\"publicationDate\":\"2012-10-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1038/nrn3353\",\"citationCount\":\"309\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Reviews Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.nature.com/articles/nrn3353\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/nrn3353","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 309

摘要

突触可塑性的 BCM 理论至今已有 30 年历史。在这篇《视角》文章中,库珀和熊讨论了这一理论如何推进了我们对突触可塑性、学习和记忆的理解,并强调了这一理论在神经科学研究中的重要作用。自埃利-比年斯托克(Elie Bienenstock)、莱昂-库珀(Leon Cooper)和保罗-芒罗(Paul Munro)的 "神经元选择性发展理论:视觉皮层的方向特异性和双目相互作用"(即突触可塑性的 BCM 理论)发表以来,30 年过去了。该理论指导实验人员发现了突触可塑性的一些基本特性,并提供了一种数学结构,将学习和记忆存储的分子机制与系统级后果联系起来。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
The BCM theory of synapse modification at 30: interaction of theory with experiment
The BCM theory of synaptic plasticity is now 30 years old. In this Perspective article, Cooper and Bear discuss how this theory has advanced our understanding of synaptic plasticity, learning and memory and highlight the important role that theory can have in neuroscience research. Thirty years have passed since the publication of Elie Bienenstock, Leon Cooper and Paul Munro''s ''Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex'', known as the BCM theory of synaptic plasticity. This theory has guided experimentalists to discover some fundamental properties of synaptic plasticity and has provided a mathematical structure that bridges molecular mechanisms and systems-level consequences of learning and memory storage.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.60%
发文量
104
期刊介绍: Nature Reviews Neuroscience is a multidisciplinary journal that covers various fields within neuroscience, aiming to offer a comprehensive understanding of the structure and function of the central nervous system. Advances in molecular, developmental, and cognitive neuroscience, facilitated by powerful experimental techniques and theoretical approaches, have made enduring neurobiological questions more accessible. Nature Reviews Neuroscience serves as a reliable and accessible resource, addressing the breadth and depth of modern neuroscience. It acts as an authoritative and engaging reference for scientists interested in all aspects of neuroscience.
期刊最新文献
Opening the gate to regeneration Fly connectome over the wire Neurobiology of attention-deficit hyperactivity disorder: historical challenges and emerging frontiers Social and emotional learning in the cerebellum Synaptic sleep pressure
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1