{"title":"30 岁突触修饰的 BCM 理论:理论与实验的互动","authors":"Leon N Cooper, Mark F. Bear","doi":"10.1038/nrn3353","DOIUrl":null,"url":null,"abstract":"The BCM theory of synaptic plasticity is now 30 years old. In this Perspective article, Cooper and Bear discuss how this theory has advanced our understanding of synaptic plasticity, learning and memory and highlight the important role that theory can have in neuroscience research. Thirty years have passed since the publication of Elie Bienenstock, Leon Cooper and Paul Munro''s ''Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex'', known as the BCM theory of synaptic plasticity. This theory has guided experimentalists to discover some fundamental properties of synaptic plasticity and has provided a mathematical structure that bridges molecular mechanisms and systems-level consequences of learning and memory storage.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"13 11","pages":"798-810"},"PeriodicalIF":28.7000,"publicationDate":"2012-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/nrn3353","citationCount":"309","resultStr":"{\"title\":\"The BCM theory of synapse modification at 30: interaction of theory with experiment\",\"authors\":\"Leon N Cooper, Mark F. Bear\",\"doi\":\"10.1038/nrn3353\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The BCM theory of synaptic plasticity is now 30 years old. In this Perspective article, Cooper and Bear discuss how this theory has advanced our understanding of synaptic plasticity, learning and memory and highlight the important role that theory can have in neuroscience research. Thirty years have passed since the publication of Elie Bienenstock, Leon Cooper and Paul Munro''s ''Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex'', known as the BCM theory of synaptic plasticity. This theory has guided experimentalists to discover some fundamental properties of synaptic plasticity and has provided a mathematical structure that bridges molecular mechanisms and systems-level consequences of learning and memory storage.\",\"PeriodicalId\":49142,\"journal\":{\"name\":\"Nature Reviews Neuroscience\",\"volume\":\"13 11\",\"pages\":\"798-810\"},\"PeriodicalIF\":28.7000,\"publicationDate\":\"2012-10-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1038/nrn3353\",\"citationCount\":\"309\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Reviews Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.nature.com/articles/nrn3353\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/nrn3353","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
The BCM theory of synapse modification at 30: interaction of theory with experiment
The BCM theory of synaptic plasticity is now 30 years old. In this Perspective article, Cooper and Bear discuss how this theory has advanced our understanding of synaptic plasticity, learning and memory and highlight the important role that theory can have in neuroscience research. Thirty years have passed since the publication of Elie Bienenstock, Leon Cooper and Paul Munro''s ''Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex'', known as the BCM theory of synaptic plasticity. This theory has guided experimentalists to discover some fundamental properties of synaptic plasticity and has provided a mathematical structure that bridges molecular mechanisms and systems-level consequences of learning and memory storage.
期刊介绍:
Nature Reviews Neuroscience is a multidisciplinary journal that covers various fields within neuroscience, aiming to offer a comprehensive understanding of the structure and function of the central nervous system. Advances in molecular, developmental, and cognitive neuroscience, facilitated by powerful experimental techniques and theoretical approaches, have made enduring neurobiological questions more accessible. Nature Reviews Neuroscience serves as a reliable and accessible resource, addressing the breadth and depth of modern neuroscience. It acts as an authoritative and engaging reference for scientists interested in all aspects of neuroscience.