用于国际 SPECT 图像定量比较的可溯源固体模拟 (131)I 模型的校准。

IF 1.5 4区 工程技术 Journal of Research of the National Institute of Standards and Technology Pub Date : 2013-08-15 eCollection Date: 2013-01-01 DOI:10.6028/jres.118.017
B E Zimmerman, L Pibida, L E King, D E Bergeron, J T Cessna, M M Mille
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引用次数: 0

摘要

国际原子能机构(IAEA)组织了一次国际比较,以评估 12 个国家的单光子发射计算机断层扫描(SPECT)图像量化能力。由于碘-131 在全球的广泛使用,因此被选为此次比对的放射性核素,但由于后勤原因,我们使用了固体 (133)Ba 源作为 (131)I 的长寿命替代物。在这项研究中,我们设计了一套固体圆柱形源,这样每个研究地点都可以拥有一套具有可追溯放射性校准的模型(标称体积分别为 2 mL、4 mL、6 mL 和 23 mL),从而可以对结果进行适当的比较。我们还开发了一种技术,使用两种不同的检测方法,根据国家标准对 (133)Ba 放射性活度源进行单独校准。这种方法可对每个 (133)Ba 源进行放射性校准,高浓度 2、4 和 6 毫升源的放射性标准不确定性为 1.4%,低浓度 23 毫升气瓶的放射性标准不确定性为 1.7%。这一不确定性水平使这些放射源可用于预期的比较工作以及其他 SPECT 图像量化研究。
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Calibration of Traceable Solid Mock (131)I Phantoms Used in an International SPECT Image Quantification Comparison.

The International Atomic Energy Agency (IAEA) has organized an international comparison to assess Single Photon Emission Computed Tomography (SPECT) image quantification capabilities in 12 countries. Iodine-131 was chosen as the radionuclide for the comparison because of its wide use around the world, but for logistical reasons solid (133)Ba sources were used as a long-lived surrogate for (131)I. For this study, we designed a set of solid cylindrical sources so that each site could have a set of phantoms (having nominal volumes of 2 mL, 4 mL, 6 mL, and 23 mL) with traceable activity calibrations so that the results could be properly compared. We also developed a technique using two different detection methods for individually calibrating the sources for (133)Ba activity based on a National standard. This methodology allows for the activity calibration of each (133)Ba source with a standard uncertainty on the activity of 1.4 % for the high-level 2-, 4-, and 6-mL sources and 1.7 % for the lower-level 23 mL cylinders. This level of uncertainty allows for these sources to be used for the intended comparison exercise, as well as in other SPECT image quantification studies.

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期刊介绍: The Journal of Research of the National Institute of Standards and Technology is the flagship publication of the National Institute of Standards and Technology. It has been published under various titles and forms since 1904, with its roots as Scientific Papers issued as the Bulletin of the Bureau of Standards. In 1928, the Scientific Papers were combined with Technologic Papers, which reported results of investigations of material and methods of testing. This new publication was titled the Bureau of Standards Journal of Research. The Journal of Research of NIST reports NIST research and development in metrology and related fields of physical science, engineering, applied mathematics, statistics, biotechnology, information technology.
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