基于图像的肺计算流体动力学:虚拟现实还是新的临床实践?

IF 7.9 Q1 Medicine Wiley Interdisciplinary Reviews-Systems Biology and Medicine Pub Date : 2017-11-01 Epub Date: 2017-06-13 DOI:10.1002/wsbm.1392
Kelly S Burrowes, Jan De Backer, Haribalan Kumar
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引用次数: 20

摘要

个性化医疗的发展和实施对于提高患者护理的效率和疗效至关重要。在呼吸系统中,功能很大程度上是由空气和血液到气体交换表面的精心设计的运动决定的。空气通过口或鼻从上呼吸道开始,并在肺泡界面终止,同时血液从心脏流到肺泡,然后再流回来。计算流体动力学(CFD)是一种成熟的预测复杂系统内流体流动和压力分布的工具。传统上,CFD一直用于帮助有效或改进系统或设备的设计;然而,它越来越多地应用于基于生物和医学的应用,进一步扩大了这种计算技术的范围。本文综述了CFD在呼吸系统中的应用进展,以及CFD在改善精准医疗方面的贡献。CFD在肺系统中应用的关键领域是预测气道内的流体输送和气溶胶分布。在这里,我们集中讨论流体流动,特别是基于图像的临床聚焦CFD在通气系统。我们讨论的研究跨越从鼻窦通过传导气道到肺泡气道的水平。成像和CFD的结合可以改善气溶胶运输的设备设计,改善临床试验中肺功能的生物标志物,并改善鼻窦手术干预的预测和评估。中国生物医学工程学报,2017,39(9):1392 - 1392。doi: 10.1002 / wsbm.1392有关与本文相关的更多资源,请访问WIREs网站。
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Image-based computational fluid dynamics in the lung: virtual reality or new clinical practice?

The development and implementation of personalized medicine is paramount to improving the efficiency and efficacy of patient care. In the respiratory system, function is largely dictated by the choreographed movement of air and blood to the gas exchange surface. The passage of air begins in the upper airways, either via the mouth or nose, and terminates at the alveolar interface, while blood flows from the heart to the alveoli and back again. Computational fluid dynamics (CFD) is a well-established tool for predicting fluid flows and pressure distributions within complex systems. Traditionally CFD has been used to aid in the effective or improved design of a system or device; however, it has become increasingly exploited in biological and medical-based applications further broadening the scope of this computational technique. In this review, we discuss the advancement in application of CFD to the respiratory system and the contributions CFD is currently making toward improving precision medicine. The key areas CFD has been applied to in the pulmonary system are in predicting fluid transport and aerosol distribution within the airways. Here we focus our discussion on fluid flows and in particular on image-based clinically focused CFD in the ventilatory system. We discuss studies spanning from the paranasal sinuses through the conducting airways down to the level of the alveolar airways. The combination of imaging and CFD is enabling improved device design in aerosol transport, improved biomarkers of lung function in clinical trials, and improved predictions and assessment of surgical interventions in the nasal sinuses. WIREs Syst Biol Med 2017, 9:e1392. doi: 10.1002/wsbm.1392 For further resources related to this article, please visit the WIREs website.

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来源期刊
CiteScore
18.40
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Journal Name:Wiley Interdisciplinary Reviews-Systems Biology and Medicine Focus: Strong interdisciplinary focus Serves as an encyclopedic reference for systems biology research Conceptual Framework: Systems biology asserts the study of organisms as hierarchical systems or networks Individual biological components interact in complex ways within these systems Article Coverage: Discusses biology, methods, and models Spans systems from a few molecules to whole species Topical Coverage: Developmental Biology Physiology Biological Mechanisms Models of Systems, Properties, and Processes Laboratory Methods and Technologies Translational, Genomic, and Systems Medicine
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