肌肉骨骼系统的内稳态和紊乱。类固醇治疗对肌肉骨骼系统的影响。

Clinical calcium Pub Date : 2018-01-01 DOI:CliCa1803402409
Hirotoshi Tanaka
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引用次数: 0

摘要

当以药理学剂量给药糖皮质激素或库欣综合征时发生肌肉萎缩,这种病理状况称为类固醇肌病。从骨骼肌中类固醇受体介导的基因表达调控机制的研究出发,进一步向转译研究方向发展,阐明类固醇通过骨骼肌参与调节全身能量代谢的机制。
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[Homeostasis and Disorder of Musculoskeletal System.Influence of steroid therapy on muscuoskeletal system.]

Muscle atrophy occurs when glucocorticoid steroids are administered in pharmacological doses or in Cushing syndrome, and such pathological condition is termed as steroid myopathy. Its molecular mechanism is clarified from the study of the gene expression regulation mechanism mediated by steroid receptors in skeletal muscle, progressing to translational research and also addressing the mechanism by which steroids participate in the regulation of whole body energy metabolism via skeletal muscle.

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