叶酸介导的单碳代谢的细胞周期调控。

IF 7.9 Q1 Medicine Wiley Interdisciplinary Reviews-Systems Biology and Medicine Pub Date : 2018-11-01 Epub Date: 2018-06-11 DOI:10.1002/wsbm.1426
Xu Lan, Martha S Field, Patrick J Stover
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引用次数: 59

摘要

叶酸介导的单碳代谢(FOCM)包括一个相互关联的叶酸依赖代谢途径网络,负责丝氨酸和甘氨酸的相互转化,从头合成嘌呤,从头合成胸苷酸和同型半胱氨酸再甲基化为蛋氨酸。这些途径分别分布在细胞质、细胞核和线粒体中。由于细胞内叶酸浓度有限,FOCM网络中的单个酶会竞争叶酸辅助因子。虽然有反馈机制调节叶酸辅助因子在叶酸依赖通路中的分配,但很少认识到细胞周期调节对FOCM的影响。本文综述了哺乳动物细胞周期中FOCM网络中酶的表达、活性和细胞定位的时间调控证据。本文分类为:生物机制>代谢生理学>健康与疾病中的哺乳动物生理学。
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Cell cycle regulation of folate-mediated one-carbon metabolism.

Folate-mediated one-carbon metabolism (FOCM) comprises a network of interconnected folate-dependent metabolic pathways responsible for serine and glycine interconversion, de novo purine synthesis, de novo thymidylate synthesis and homocysteine remethylation to methionine. These pathways are compartmentalized in the cytosol, nucleus and mitochondria. Individual enzymes within the FOCM network compete for folate cofactors because intracellular folate concentrations are limiting. Although there are feedback mechanisms that regulate the partitioning of folate cofactors among the folate-dependent pathways, less recognized is the impact of cell cycle regulation on FOCM. This review summarizes the evidence for temporal regulation of expression, activity and cellular localization of enzymes and pathways in the FOCM network in mammalian cells through the cell cycle. This article is categorized under: Biological Mechanisms > Metabolism Physiology > Mammalian Physiology in Health and Disease.

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来源期刊
CiteScore
18.40
自引率
0.00%
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0
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>12 weeks
期刊介绍: Journal Name:Wiley Interdisciplinary Reviews-Systems Biology and Medicine Focus: Strong interdisciplinary focus Serves as an encyclopedic reference for systems biology research Conceptual Framework: Systems biology asserts the study of organisms as hierarchical systems or networks Individual biological components interact in complex ways within these systems Article Coverage: Discusses biology, methods, and models Spans systems from a few molecules to whole species Topical Coverage: Developmental Biology Physiology Biological Mechanisms Models of Systems, Properties, and Processes Laboratory Methods and Technologies Translational, Genomic, and Systems Medicine
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