O S Alekseyeva, Ye G Gillerovich, O V Kirik, D E Korzhevskiy
{"title":"[兔小脑皮层分子层小胶质细胞的结构和空间组织]。","authors":"O S Alekseyeva, Ye G Gillerovich, O V Kirik, D E Korzhevskiy","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Using the methods of immunocytochemistry and\nconfocal laser microscopy, structural organization\nand spatial distribution of microgliocytes in the\nmolecular layer of the cerebellar cortex were\nstudied in 5 adult male rabbits. Reaction to\nmicroglial cell marker Iba-1 was highly specific,\nwhile until recently their selective detection was\nimpossible in rabbits. In the molecular layer of the\ncerebellar cortex, two patterns of microgliocyte\norganization were observed. Most common were\nthe cells with tortuous intricately ramified\nprocesses, the main branches of which often had\nradial direction. Perivascular sparsely-branched\nspindleshaped microgliocytes were also found. The\npeculiarities of the structural organization of these\ncells are related to the protective functions they\nperform at the level of the blood-brain barrier.</p>","PeriodicalId":74226,"journal":{"name":"Morfologiia (Saint Petersburg, Russia)","volume":"150 4","pages":"40-3"},"PeriodicalIF":0.0000,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[STRUCTURAL AND SPATIAL ORGANIZATION OF MICROGLIA IN THE MOLECULAR LAYER OF RABBIT CEREBELLAR CORTEX].\",\"authors\":\"O S Alekseyeva, Ye G Gillerovich, O V Kirik, D E Korzhevskiy\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Using the methods of immunocytochemistry and\\nconfocal laser microscopy, structural organization\\nand spatial distribution of microgliocytes in the\\nmolecular layer of the cerebellar cortex were\\nstudied in 5 adult male rabbits. Reaction to\\nmicroglial cell marker Iba-1 was highly specific,\\nwhile until recently their selective detection was\\nimpossible in rabbits. In the molecular layer of the\\ncerebellar cortex, two patterns of microgliocyte\\norganization were observed. Most common were\\nthe cells with tortuous intricately ramified\\nprocesses, the main branches of which often had\\nradial direction. Perivascular sparsely-branched\\nspindleshaped microgliocytes were also found. The\\npeculiarities of the structural organization of these\\ncells are related to the protective functions they\\nperform at the level of the blood-brain barrier.</p>\",\"PeriodicalId\":74226,\"journal\":{\"name\":\"Morfologiia (Saint Petersburg, Russia)\",\"volume\":\"150 4\",\"pages\":\"40-3\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Morfologiia (Saint Petersburg, Russia)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Morfologiia (Saint Petersburg, Russia)","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[STRUCTURAL AND SPATIAL ORGANIZATION OF MICROGLIA IN THE MOLECULAR LAYER OF RABBIT CEREBELLAR CORTEX].
Using the methods of immunocytochemistry and
confocal laser microscopy, structural organization
and spatial distribution of microgliocytes in the
molecular layer of the cerebellar cortex were
studied in 5 adult male rabbits. Reaction to
microglial cell marker Iba-1 was highly specific,
while until recently their selective detection was
impossible in rabbits. In the molecular layer of the
cerebellar cortex, two patterns of microgliocyte
organization were observed. Most common were
the cells with tortuous intricately ramified
processes, the main branches of which often had
radial direction. Perivascular sparsely-branched
spindleshaped microgliocytes were also found. The
peculiarities of the structural organization of these
cells are related to the protective functions they
perform at the level of the blood-brain barrier.