[兔小脑皮层分子层小胶质细胞的结构和空间组织]。

O S Alekseyeva, Ye G Gillerovich, O V Kirik, D E Korzhevskiy
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引用次数: 0

摘要

采用免疫细胞化学和激光共聚焦显微镜方法,对5只成年雄性家兔小脑皮层分子层小胶质细胞的结构组织和空间分布进行了研究。对小胶质细胞标志物Iba-1的反应是高度特异性的,而直到最近它们的选择性检测是不可能的。在小脑皮层分子层,观察到两种小胶质细胞组织模式。最常见的是具有曲折复杂分枝突起的细胞,其主要分支通常是径向的。血管周围也可见稀疏分支的纺锤状小胶质细胞。这些细胞结构组织的特殊性与它们在血脑屏障水平上执行的保护功能有关。
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[STRUCTURAL AND SPATIAL ORGANIZATION OF MICROGLIA IN THE MOLECULAR LAYER OF RABBIT CEREBELLAR CORTEX].

Using the methods of immunocytochemistry and confocal laser microscopy, structural organization and spatial distribution of microgliocytes in the molecular layer of the cerebellar cortex were studied in 5 adult male rabbits. Reaction to microglial cell marker Iba-1 was highly specific, while until recently their selective detection was impossible in rabbits. In the molecular layer of the cerebellar cortex, two patterns of microgliocyte organization were observed. Most common were the cells with tortuous intricately ramified processes, the main branches of which often had radial direction. Perivascular sparsely-branched spindleshaped microgliocytes were also found. The peculiarities of the structural organization of these cells are related to the protective functions they perform at the level of the blood-brain barrier.

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