长链非编码rna在造血调节中的作用

IF 4 Q2 CELL & TISSUE ENGINEERING Cell Regeneration Pub Date : 2018-12-01 DOI:10.1016/j.cr.2018.08.001

Weiqian Li , Yue Ren , Yanmin Si , Fang Wang , Jia Yu

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引用次数: 16

摘要

长链非编码RNA (lncRNAs)通过与DNA、RNA或蛋白质的结合在多种生物过程中发挥着至关重要的作用。这些lncrna介导的相互作用增强了基因调控网络并调节了广泛的下游基因。已经证明，几种lncrna在造血过程中起着关键的调节作用。这篇综述强调了lncRNA在正常造血发育中的作用，并讨论了lncRNA失调如何与疾病预后和表型相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Long non-coding RNAs in hematopoietic regulation

Long non-coding RNAs (lncRNAs) have crucial roles via tethering with DNA, RNA or protein in diverse biological processes. These lncRNA-mediated interactions enhance gene regulatory networks and modulate a wide range of downstream genes. It has been demonstrated that several lncRNAs act as key regulators in hematopoiesis. This review highlights the roles of lncRNAs in normal hematopoietic development and discusses how lncRNA dysregulation correlates with disease prognoses and phenotypes.

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来源期刊

Cell Regeneration Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

5.80

自引率

0.00%

发文量

审稿时长

35 days

期刊介绍： Cell Regeneration aims to provide a worldwide platform for researches on stem cells and regenerative biology to develop basic science and to foster its clinical translation in medicine. Cell Regeneration welcomes reports on novel discoveries, theories, methods, technologies, and products in the field of stem cells and regenerative research, the journal is interested, but not limited to the following topics: ◎ Embryonic stem cells ◎ Induced pluripotent stem cells ◎ Tissue-specific stem cells ◎ Tissue or organ regeneration ◎ Methodology ◎ Biomaterials and regeneration ◎ Clinical translation or application in medicine