[中线腹侧被盖区单次注射脑源性神经营养因子对吗啡增强特性的影响]。

IF 0.2 4区 医学 Q4 NEUROSCIENCES Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova Pub Date : 2016-09-01
D I Peregud, M Yu Stepanichev, N A Lazareva, L F Panchenko, N V Gulyaeva
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引用次数: 0

摘要

阿片强化被认为是一种诱发成瘾的刺激,但其潜在的神经生物学机制尚不清楚。据文献报道,BDNF (brain-derived neurotrophic factor,脑源性神经营养因子)在侧腹侧被盖区(VTA)可调节吗啡强化,但BDNF在中线VTA中的作用尚未研究。本研究旨在探讨单次中线内VTA注射对吗啡条件位置偏好(CPP)获得和表达的影响。CPP过程由8个调节阶段(每天1个阶段)组成:吗啡(i.p, 10 mg/kg)和生理盐水注射与室配对并平衡。重组人BDNF (0.75 ug)或磷酸盐缓冲盐水(PBS)作为载体,在调理前后一天注射一次中线VTA。CPP实验显示,吗啡组大鼠待在吗啡组的时间比盐水组大鼠多(p < 0.05)。调节前单次注射BDNF,调节后不注射BDNF,吗啡和盐水配对室的时间差异无统计学意义(p > 0.05)。因此,考虑到结果的局限性,我们认为VTA中线的BDNF可能会阻断吗啡的强化。
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[Effect of a Single Injection of Brain Derived Neurotrophic Factor into Midline Ventral Tegmental Area on Morphine Reinforcing Properties].

Opiate reinforcement is considered as a stimulus inducing addiction, however underlying neurobiological mechanisms remain obscure. According to the literature, BDNF (brain-derived neurotrophic factor) in the lateral ventral tegmental area (VTA) could modulate morphine reinforcement, but the role of BDNF in the midline VTA has not been studied yet. The aim of the study was to investigate the effect of a single intra-mid- line VTA injection on the acquisition and expression of morphine conditioned place preference (CPP). CPP procedure was composed of eight conditioning sessions (one session per day): morphine (i.p., 10 mg/kg) and saline injections were paired to the compartments and counterbalanced.Recombinant human BDNF (0.75 ug) or phosphate-buffered saline (PBS) as a vehicle were injected once into the midline VTA one day before or after conditioning. According to the CPP test rats spent more time in the morphine-paired compartments a scompared to the saline-paired compartments (p < 0.05). After a single BDNF injection into the midline VTA be- fore conditioning, but not after conditioning, differences in time spent in morphine and saline-paired compartments did not reach significance (p > 0.05). Thus, taking into account limitations of the results, we sug- gest that BDNF in the midline VTA may block morphine reinforcement.

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来源期刊
CiteScore
0.70
自引率
33.30%
发文量
9
审稿时长
6-12 weeks
期刊介绍: Information not localized
期刊最新文献
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