人类微生物群在健康和疾病中的作用:炒作还是希望。

IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Acta Clinica Belgica Pub Date : 2019-04-01 Epub Date: 2019-02-27 DOI:10.1080/17843286.2019.1583782
Gwen Falony, Doris Vandeputte, Clara Caenepeel, Sara Vieira-Silva, Tanine Daryoush, Séverine Vermeire, Jeroen Raes
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引用次数: 35

摘要

目的:人类肠道菌群的预后、诊断和治疗潜力已得到广泛认可。然而,将微生物组的发现转化为临床实践是具有挑战性的。在这里,我们将讨论该领域的当前知识和应用。方法:我们回顾了粪便微生物组分析领域的一些最新进展,重点是协变量分析和生态学解释。结果:健康志愿者肠道微生物群变异的人群水平表征允许确定临床研究所需的微生物组协变量。目前,微生物组研究正从相对方法转向定量方法,这将为健康和疾病中的微生物-宿主相互作用提供新的线索。结论:协变量表征和技术进步提高了微生物组研究的可重复性。有针对性的体外/体内干预研究将加速微生物群研究结果的临床应用。
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The human microbiome in health and disease: hype or hope.

Objectives: The prognostic, diagnostic, and therapeutic potential of the human gut microbiota is widely recognised. However, translation of microbiome findings to clinical practice is challenging. Here, we discuss current knowledge and applications in the field.

Methods: We revisit some recent advances in the field of faecal microbiome analyses with a focus on covariate analyses and ecological interpretation.

Results: Population-level characterization of gut microbiota variation among healthy volunteers has allowed identifying microbiome covariates required for clinical studies. Currently, microbiome research is moving from relative to quantitative approaches that will shed a new light on microbiota-host interactions in health and disease.

Conclusions: Covariate characterization and technical advances increase reproducibility of microbiome research. Targeted in vitro/in vivo intervention studies will accelerate clinical implementation of microbiota findings.

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来源期刊
Acta Clinica Belgica
Acta Clinica Belgica MEDICINE, GENERAL & INTERNAL-
CiteScore
3.50
自引率
0.00%
发文量
44
期刊介绍: Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine primarily publishes papers on clinical medicine, clinical chemistry, pathology and molecular biology, provided they describe results which contribute to our understanding of clinical problems or describe new methods applicable to clinical investigation. Readership includes physicians, pathologists, pharmacists and physicians working in non-academic and academic hospitals, practicing internal medicine and its subspecialties.
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