细胞内信号动力学及其在协调组织修复中的作用。

IF 7.9 Q1 Medicine Wiley Interdisciplinary Reviews-Systems Biology and Medicine Pub Date : 2020-05-01 Epub Date: 2020-02-08 DOI:10.1002/wsbm.1479
Samuel J Ghilardi, Breanna M O'Reilly, Allyson E Sgro
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引用次数: 28

摘要

组织修复是一个复杂的过程,需要在多个组织和器官系统的细胞之间进行有效的沟通和协调。编码损伤信号并启动组织修复反应的两个初始细胞内信号是钙和细胞外信号调节激酶(ERK)。然而,钙和ERK信号控制着多种对损伤修复很重要的细胞行为,包括细胞运动性、收缩性和增殖,以及几种不同转录因子的活性,这使得将特定损伤信号与各自的修复程序联系起来具有挑战性。这种知识差距最终阻碍了新的伤口愈合疗法的发展,这些疗法可以利用天然细胞信号程序更有效地修复组织损伤。这篇综述的目的是强调钙和ERK信号动力学的作用,作为在上皮和间质损伤修复过程中将特定损伤信号与特定细胞修复程序联系起来的机制。随着新的生物传感器和光遗传信号控制器的出现,我们详细介绍了控制钙和ERK的信号网络现在如何使用经典的信号处理技术进行剖析。最后,我们主张认识到钙和ERK动力学作为损伤检测和损伤修复程序之间的关键环节的重要性,这些程序在不同组织和器官的细胞之间组织和执行协调的组织修复反应。本文被分类为:系统特性和过程模型>机制模型生物学机制>细胞信号实验室方法和技术>系统特性和过程成像模型>器官、组织和生理模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Intracellular signaling dynamics and their role in coordinating tissue repair.

Tissue repair is a complex process that requires effective communication and coordination between cells across multiple tissues and organ systems. Two of the initial intracellular signals that encode injury signals and initiate tissue repair responses are calcium and extracellular signal-regulated kinase (ERK). However, calcium and ERK signaling control a variety of cellular behaviors important for injury repair including cellular motility, contractility, and proliferation, as well as the activity of several different transcription factors, making it challenging to relate specific injury signals to their respective repair programs. This knowledge gap ultimately hinders the development of new wound healing therapies that could take advantage of native cellular signaling programs to more effectively repair tissue damage. The objective of this review is to highlight the roles of calcium and ERK signaling dynamics as mechanisms that link specific injury signals to specific cellular repair programs during epithelial and stromal injury repair. We detail how the signaling networks controlling calcium and ERK can now also be dissected using classical signal processing techniques with the advent of new biosensors and optogenetic signal controllers. Finally, we advocate the importance of recognizing calcium and ERK dynamics as key links between injury detection and injury repair programs that both organize and execute a coordinated tissue repair response between cells across different tissues and organs. This article is categorized under: Models of Systems Properties and Processes > Mechanistic Models Biological Mechanisms > Cell Signaling Laboratory Methods and Technologies > Imaging Models of Systems Properties and Processes > Organ, Tissue, and Physiological Models.

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来源期刊
CiteScore
18.40
自引率
0.00%
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0
审稿时长
>12 weeks
期刊介绍: Journal Name:Wiley Interdisciplinary Reviews-Systems Biology and Medicine Focus: Strong interdisciplinary focus Serves as an encyclopedic reference for systems biology research Conceptual Framework: Systems biology asserts the study of organisms as hierarchical systems or networks Individual biological components interact in complex ways within these systems Article Coverage: Discusses biology, methods, and models Spans systems from a few molecules to whole species Topical Coverage: Developmental Biology Physiology Biological Mechanisms Models of Systems, Properties, and Processes Laboratory Methods and Technologies Translational, Genomic, and Systems Medicine
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