免疫Warburg效应:自身免疫的证据和治疗机会。

IF 7.9 Q1 Medicine Wiley Interdisciplinary Reviews-Systems Biology and Medicine Pub Date : 2020-09-01 Epub Date: 2020-02-27 DOI:10.1002/wsbm.1486
Michael D Kornberg
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引用次数: 49

摘要

促炎信号诱导骨髓和淋巴系先天和适应性免疫细胞的代谢重编程,其特征是向有氧糖酵解的转变,类似于最初在癌症中描述的Warburg效应。阻断向有氧糖酵解的转换会损害促炎细胞类型的存活、分化和效应功能,同时有利于抗炎和调节表型。因此,糖酵解重编程可能代表了炎症免疫细胞的一种选择性脆弱性,为调节自身免疫性疾病中的免疫反应提供了机会,而不会对身体其他组织产生广泛的毒性。有氧糖酵解和糖酵解与氧化磷酸化之间的平衡调节免疫反应的机制才刚刚开始被理解,预计在未来几年还会有更多的见解。针对有氧糖酵解的免疫代谢疗法包括关键酶的药理学抑制剂和葡萄糖限制饮食,如生酮饮食。动物研究支持这些药理学和饮食疗法在治疗自身免疫性疾病中的作用,在少数情况下,概念的证明已在人类疾病中得到证实。尽管如此,需要做更多的工作来确定这些治疗的临床安全性和有效性。本文分类如下:生物学机制>代谢、转化、基因组和系统医学>转化医学生物学机制>细胞信号传导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The immunologic Warburg effect: Evidence and therapeutic opportunities in autoimmunity.

Pro-inflammatory signals induce metabolic reprogramming in innate and adaptive immune cells of both myeloid and lymphoid lineage, characterized by a shift to aerobic glycolysis akin to the Warburg effect first described in cancer. Blocking the switch to aerobic glycolysis impairs the survival, differentiation, and effector functions of pro-inflammatory cell types while favoring anti-inflammatory and regulatory phenotypes. Glycolytic reprogramming may therefore represent a selective vulnerability of inflammatory immune cells, providing an opportunity to modulate immune responses in autoimmune disease without broad toxicity in other tissues of the body. The mechanisms by which aerobic glycolysis and the balance between glycolysis and oxidative phosphorylation regulate immune responses have only begun to be understood, with many additional insights expected in the years to come. Immunometabolic therapies targeting aerobic glycolysis include both pharmacologic inhibitors of key enzymes and glucose-restricted diets, such as the ketogenic diet. Animal studies support a role for these pharmacologic and dietary therapies for the treatment of autoimmune diseases, and in a few cases proof of concept has been demonstrated in human disease. Nonetheless, much more work is needed to establish the clinical safety and efficacy of these treatments. This article is categorized under: Biological Mechanisms > Metabolism Translational, Genomic, and Systems Medicine > Translational Medicine Biological Mechanisms > Cell Signaling.

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来源期刊
CiteScore
18.40
自引率
0.00%
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0
审稿时长
>12 weeks
期刊介绍: Journal Name:Wiley Interdisciplinary Reviews-Systems Biology and Medicine Focus: Strong interdisciplinary focus Serves as an encyclopedic reference for systems biology research Conceptual Framework: Systems biology asserts the study of organisms as hierarchical systems or networks Individual biological components interact in complex ways within these systems Article Coverage: Discusses biology, methods, and models Spans systems from a few molecules to whole species Topical Coverage: Developmental Biology Physiology Biological Mechanisms Models of Systems, Properties, and Processes Laboratory Methods and Technologies Translational, Genomic, and Systems Medicine
期刊最新文献
Tools for computational analysis of moving boundary problems in cellular mechanobiology. Cellular reprogramming: Mathematics meets medicine. Thermoregulation: A journey from physiology to computational models and the intensive care unit. Mammalian cell and tissue imaging using Raman and coherent Raman microscopy. Computational models to explore the complexity of the epithelial to mesenchymal transition in cancer.
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