利什曼体阳性和阴性皮肤样品中CD1a和CD68标记物表达的比较

IF 1.4 Q4 IMMUNOLOGY American journal of clinical and experimental immunology Pub Date : 2021-08-15 eCollection Date: 2021-01-01
Fataneh Farokhpour, Parvin Rajabi, Bahare Abtahi Naeini, Azar Naimi
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引用次数: 0

摘要

背景:利什曼病是世界上最重要的传染病之一。考虑到该病的高度常见性,特别是其在伊朗的皮肤类型,以及利什曼体在诊断中的作用,本研究的目的是评估两种CD1a和CD68标记物在伴有和不伴有利什曼体的皮肤利什曼病病变中的表达。方法:采用病例-对照研究方法,对2018-2019年皮肤利什曼病患者皮肤样本70例(伴有利什曼体患者35例为病例组,未伴有利什曼男孩患者35例为对照组)进行调查。本研究观察了CD1a和CD68标志物的表达及免疫组化染色(IHC)。结果:有利什曼体组CD1a表达显著高于无利什曼体组(P=0.01),而CD68表达无显著差异(P=0.40)。利什曼体组角化过度、角化不全、胞吐、棘层增生、海绵状病、基底细胞层水样变性、地衣样反应、假上皮瘤性增生、溃疡、表皮变薄、单核细胞、炎症向真皮下层延伸的频率高于非利什曼体组(p)。CD1a的表达和其他形态学结果有助于诊断有无利什曼体的利什曼病的差异。
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Comparison of expression of CD1a and CD68 markers in skin leishmaniasis samples with positive and negative Leishman body.

Background: Leishmaniasis is one of the most important infectious illnesses around the world. Given the high commonness of this disease, specifically its skin type in Iran and due to the role of the Leishman bodies in diagnosis, the aim of present study was evaluating the expression of two CD1a and CD68 markers in cutaneous leishmaniasis lesions with and without Leishman bodies.

Methods: In this case-control study, 70 skin samples of patients with cutaneous leishmaniasis (35 patients with Leishman body as case group and 35 patients without Leishman boy as control group) were investigated during 2018-2019. The expression of CD1a and CD68 markers and immunohistochemistry staining (IHC) were investigated in this study.

Results: The expression of CD1a in the group with Leishman body was significantly higher than group without Leishman body (P=0.01), but there was no significant difference between groups as expression of CD68 (P=0.40). The frequency of hyperkeratosis, parakeratosis, exocytosis, acanthosis, spongiosis, hydropic degeneration of basal cell layer, lichenoid reaction, pseudoepitheliomatous hyperplasia, ulcer, thinning of the epidermis, mononuclear cells, and extension of inflammation into lower dermis in the group with Leishman body was higher than group without Leishman body (P<0.05).

Conclusion: The expression of CD1a and other morphological findings help to diagnose the difference between leishmaniasis with and without Leishman body.

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