RNA聚合酶III和RNA在DNA同源重组中的直接作用。

IF 2.6 Q3 ONCOLOGY Molecular and Cellular Oncology Pub Date : 2021-07-01 eCollection Date: 2021-01-01 DOI:10.1080/23723556.2021.1935173

Sijie Liu, Daochun Kong

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引用次数: 3

摘要

在DNA双链断裂修复过程中，末端切除从5'端链上切除数千个碱基，产生3'端单链DNA悬垂。这个突出部分需要严格保护，防止DNA2或其他核酸酶的消化。最近的一项研究表明，RNA- dna杂交的瞬时形成保护了3'端悬垂，RNA聚合酶III是同源重组的重要因素。

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A direct role of RNA polymerase III and RNA in DNA homologous recombination.

End resection excises several thousand bases from the 5'-ended strand during DNA double-strand break repair, creating 3'-end single-stranded DNA overhangs. This overhang requires strict protection from DNA2 or other nucleases digestion. A recent finding showed that the 3'-end overhangs are protected by the transient formation of RNA-DNA hybrids, and RNA polymerase III is an essential factor for homologous recombination.

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.