重新考虑认知筛查工具的准确性:总体、平衡还是无偏准确性?

IF 2.3 Q3 CLINICAL NEUROLOGY Neurodegenerative disease management Pub Date : 2022-04-01 Epub Date: 2022-02-18 DOI:10.2217/nmt-2021-0049
Andrew J Larner
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引用次数: 7

摘要

目的:探讨认知筛查工具评估的三种不同准确性指标:总正确分类准确率(Acc),真阳性和阴性的总和除以测试总数;平衡准确度(balanced Acc),敏感性和特异性之和的一半;和无偏准确性(unbiased Acc),消除了测试结果和疾病流行之间随机关联的偏倚效应。材料与方法:数据来自Mini-Addenbrooke认知测验的前瞻性测试准确性研究,用于计算和绘制Acc测量值。结果:每个Acc指标在Mini-Addenbrooke认知检查的范围内诊断痴呆和轻度认知障碍的结果模式相似。Acc和平衡Acc比无偏Acc给出更乐观的结果(更接近可能的最大值1)。结论:通过消除检测结果与疾病患病率之间随机关联的偏倚效应,无偏Acc可能比Acc和平衡Acc具有优势。
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Accuracy of cognitive screening instruments reconsidered: overall, balanced or unbiased accuracy?

Aim: To examine three different accuracy metrics for evaluation of cognitive screening instruments: overall correct classification accuracy (Acc), the sum of true positives and negatives divided by the total number tested; balanced accuracy (balanced Acc), half of the sum of sensitivity and specificity; and unbiased accuracy (unbiased Acc), removing biasing effects of random associations between test results and disease prevalence. Materials & methods: Data from a prospective test accuracy study of Mini-Addenbrooke's Cognitive Examination were used to calculate and plot the Acc measures. Results: Each Acc metric resulted in a similar pattern of results across the range of Mini-Addenbrooke's Cognitive Examination cut-offs for diagnosis of both dementia and mild cognitive impairment. Acc and balanced Acc gave more optimistic outcomes (closer to possible maximum value of 1) than unbiased Acc. Conclusion: Unbiased Acc may have advantages over Acc and balanced Acc by removing biasing effects of random associations between test result and disease prevalence.

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CiteScore
4.30
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0.00%
发文量
35
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