铅(化学品和污染物)。

Food safety (Tokyo, Japan) Pub Date : 2022-06-24 eCollection Date: 2022-06-01 DOI:10.14252/foodsafetyfscj.D-22-00004
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引用次数: 0

摘要

日本食品安全委员会(FSCJ)将铅(以下简称Pb)的风险评估作为一种自我任务评估。最初,卫生、劳动和福利省要求对铅进行风险评估,以修订器具/容器和包装标准(ACP)以及修订饮料标准。考虑到人体接触铅的多种方式和途径,FSCJ认为,不需要对ACP或饮料进行特定的风险评估,而需要对铅进行综合风险评估。为了估计日本普通人群的实际铅暴露情况,目前的自我任务评估工作组开始检查儿童(12岁男孩和女孩,n = 289, 2015-2018年调查)和成年人(孕妇,n = 96,696, 2011-2014年调查)的现有血液铅水平数据1)。FSCJ根据目前的数据得出结论,目前日本的平均血铅水平约为1微克/分升或更低。对先前流行病学研究结果的综合评估表明,即使血铅水平为1-2微克/分升,也可能影响儿童的神经行为发育或成人的肾功能。然而,FSCJ的结论是,从流行病学研究的数据中很难计算出没有不良影响的血铅水平。目前日本的铅水平约为1微克/分升或更低。这一数值接近流行病学研究建议的1-2微克/分升可能产生某些影响的水平。因此,需要持续实施减少铅接触的措施。通过人体生物监测密切监测血铅水平的变化趋势,也是验证减少铅暴露措施效果的必要手段。
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Lead (Chemicals and Contaminants).

Food Safety Commission of Japan (FSCJ) conducted risk assessment of lead (hereinafter referred to as Pb) as a Self-Tasking assessment. Risk assessments of Pb were initially requested from the Ministry of Health, Labour and Welfare in relation to revision of the standards for apparatus/container and packaging (ACP) and to revision of the standards for beverages. Considering the diverse modes and routes of human exposure to Pb, FSCJ judged that a comprehensive risk assessment of Pb is appropriate instead of specific risk assessment relating to ACP or beverages. To estimate the actual Pb exposure of the general population in Japan, the present Self-Tasking assessment working group started to inspect available data of blood Pb levels among children (12 years old boys and girls, n = 289, surveyed for 2015-2018) and among adults (pregnant women, n = 96,696, surveyed for 2011-2014)1). FSCJ concluded that average blood level of Pb of current Japan is about 1 µg/dL or less based on the data available at present. Comprehensive evaluation of the findings from the previous epidemiological studies suggested that even blood Pb at the level of 1-2 µg/dL potentially affected children's neuro-behavioral development or adult renal function. FSCJ, however, concluded that figuring out of a blood Pb level without adverse effects was difficult from the data of epidemiological studies. Pb level in current Japan as about 1 µg/dL or less. This value is close to the level potentially to have some effects, 1-2 µg/dL as suggested by epidemiological studies. Continuous implementation of measures to reduce Pb exposure is thus required. A close watch on the trend of blood Pb level by human biomonitoring is also necessary for verification of the efficacy of the measures to reduce Pb exposure.

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