细胞因子、趋化因子、C3a和甘露糖结合凝集素在基孔肯雅感染演变中的作用。

IF 1.4 Q4 IMMUNOLOGY American journal of clinical and experimental immunology Pub Date : 2022-06-15 eCollection Date: 2022-01-01
Berta N Restrepo, Katerine Marín, Paola Romero, Margarita Arboleda, Ana L Muñoz, Irene Bosch, Heriberto Vásquez-Serna, Orlando A Torres
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引用次数: 0

摘要

基孔肯雅热感染严重程度的发病机制尚不完全清楚。目的:探讨细胞因子/趋化因子和补体系统在基孔肯雅热感染演变中的作用。方法:测定83例基孔肯雅感染患者和10例健康对照者急性期和慢性期12种细胞因子/趋化因子和2种补体介质:甘露糖结合凝集素(MBL)和C3a的血清水平。结果:在急性期,75.9%的患者出现肌肉骨骼疾病,其中37.7%的患者持续到慢性期。总的来说,患者的细胞因子水平高于健康对照组,在IFN-γ、IL-6、IL-8、IL-10和MIP-1方面存在显著差异。大多数细胞因子在慢性期呈下降趋势。然而,只有IL-10和MIP-1水平在慢性期显著降低。此外,这些水平从未降低到健康对照组的浓度。此外,MBL水平在急性期明显高于慢性期。无论是急性期118.2(66.5-252.9),还是慢性期68.5(64.4-71.3),肌肉骨骼疾病患者的C3a水平均明显高于非肌肉骨骼疾病患者,P < 0.001。有趣的是,当患者有严重的疾病版本时,C3a水平显着升高。此外,在急性期,关节炎患者的C3a水平高于关节炎患者,分别为194.3(69.5-282.2)和70.9 (62.4-198.8),P = 0.013。结论:我们的结果显示免疫反应持续到慢性期和补体系统在疾病严重程度中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Role of cytokines, chemokines, C3a, and mannose-binding lectin in the evolution of the chikungunya infection.

The pathogenesis of the severity of chikungunya infection is not yet fully understood.

Objective: To assess the role of the cytokines/chemokines and system of complement in the evolution of chikungunya infection.

Methods: In both acute and chronic phases, we measured the serum levels of 12 cytokines/chemokines and two complement mediators: mannose-binding lectin (MBL) and C3a, in 83 patients with chikungunya infection and ten healthy controls.

Results: During the acute phase, 75.9% of the patients developed musculoskeletal disorders, and in 37.7% of them, these disorders persisted until the chronic phase. In general, patients had higher levels of cytokines than healthy controls, with significant differences for IFN-γ, IL-6, IL-8, IL-10, and MIP-1. Most cytokines exhibited a downward trend during the chronic phase. However, only IL-10, and MIP-1 levels were significantly lower in the chronic phase. Additionally, these levels never decreased to concentrations found in healthy controls. Moreover, MBL levels were significantly higher in the acute phase compared with the chronic phase. C3a levels were significantly higher in patients with musculoskeletal disorder compared with patients without it, in both acute-phase 118.2 (66.5-252.9), and chronic phase 68.5 (64.4-71.3), P < 0.001. Interestingly, C3a levels were significantly higher when patients had a severe disease version. Besides, in the acute phase, C3a levels were higher in patients that suffer arthritis as opposed to when they suffer arthralgia, 194.3 (69.5-282.2), and 70.9 (62.4-198.8), P = 0.013, respectively.

Conclusions: Our results showed an immunological response that persisted until the chronic phase and the role of the complement system in the severity of the disease.

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