Kimberley C Clark, Yunjian Wu, Renea A Taylor, Roger J Daly
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引用次数: 1
摘要
尽管在治疗方面取得了进展,但前列腺癌仍然是世界范围内发病率和死亡率的重要原因。虽然绝大多数前列腺癌研究都集中在恶性上皮细胞上,但肿瘤微环境(tumor mi - cross - environment, TME)最近越来越被认为是肿瘤进展和治疗反应的重要调节因子。在TME内的多种细胞类型中,间质成纤维细胞,特别是癌症相关成纤维细胞(CAFs),在前列腺癌的进展中起着重要作用。CAF标志物在前列腺癌中的预后价值突出了这一点,它可以预测疾病的复发、转移和患者的生存。也有越来越多的研究表明,CAF在介导对特定治疗的反应以及作为潜在治疗靶点的CAF信号通路方面发挥着关键作用。然而,需要进一步研究癌细胞与CAFs之间相互作用的机制,以开发新的治疗方法,并确定CAFs中的预测和预后生物标志物。在这篇综述中,我们讨论了目前对前列腺肿瘤发生中ca依赖的调节途径及其预后和治疗潜力的了解。此外,我们还探索了新兴的模型和技术,这些模型和技术可能会在发现和转化为临床方面推进这一研究领域。
Novel Therapeutic Targets and Biomarkers Associated with Prostate Cancer-Associated Fibroblasts (CAFs).
Despite advances in treatment, prostate cancer remains a significant cause of morbidity and mortality worldwide. While the vast majority of prostate cancer research has centered on malignant epithelial cells, the tumor mi croenvironment (TME) has recently become increasingly recognized as an important regulator of tumor progression and response to treatment. Among the diverse cell types within the TME, stromal fibroblasts, in particular cancer-associated fibroblasts (CAFs), play an important role in prostate cancer progression. This is highlighted by the prognostic value of CAF markers in prostate cancer, which can predict disease recurrence, metastasis, and patient survival. There are also an increasing number of studies that demonstrate the critical role of CAFs in mediating response to specific therapies and CAF signaling pathways as potential therapeutic targets. However, further investigation into the mechanisms that underpin the interactions between cancer cells and CAFs are required to develop novel therapeutic approaches and identify predictive and prognostic biomarkers in CAFs. In this review, we discuss the current knowledge of CAF-dependent regulatory pathways in prostate tumorigenesis and their prognostic and therapeutic potential. Furthermore, we explore the emerging models and technologies that are likely to progress this field of research in terms of discovery and translation to the clinic.
期刊介绍:
The journal is dedicated to extensive reviews, minireviews, and special theme issues on topics of current interest in basic and patient-oriented cancer research. The study of systems biology of cancer with its potential for molecular level diagnostics and treatment implies competence across the sciences and an increasing necessity for cancer researchers to understand both the technology and medicine. The journal allows readers to adapt a better understanding of various fields of molecular oncology. We welcome articles on basic biological mechanisms relevant to cancer such as DNA repair, cell cycle, apoptosis, angiogenesis, tumor immunology, etc.